Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PIWI-interacting RNA"”.
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Analysis of variation in PIWI-interacting RNA (piRNA) expression in testes of different mouse strains
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs present in the germline of most animals which are responsible for silencing transposable elements (TEs) through base-pair complementarity. We performed an extensive study of the expression of piRNAs in the male germline of five …
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
The PIWI-interacting RNA (piRNA) pathway is a small RNA based intracellular immune system protecting animal gonads from the deleterious effects of transposons, thus maintaining transgenerational genome integrity. In Drosophila melanogaster ovaries, piRNA-Piwi complexes localise to the nucleus and …
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Transcriptional regulation of the piRNA pathway in animal ovarian germ cells
The PIWI-interacting RNA (piRNA) pathway is a deeply conserved mechanism by which animals guard their genomes against the activity of mobile genetic elements. The gene-regulatory networks controlling the expression of the germline piRNA pathway components within the gonads of metazoan species …
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Insights into the piRNA pathway through 16 strains of mice
… several classes of non-coding regulatory RNAs. One such class of small RNAs - PIWI-interacting RNA (piRNAs) - are exclusively expressed in the germlines of mammals. This thesis provides an exhaustive bioinformatic exploration of piRNA biogenesis and dynamics utilising a large …
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Evolutionary conservation of unistrand piRNA clusters and characterisation of the piRNA precursor export machinery in Drosophila
The PIWI-interacting RNA (piRNA) pathway prevents endogenous genomic parasites, transposable elements, from damaging the genetic material of animal gonadal cells. Specific regions in the genome, called piRNA clusters, are thought to define each species’ piRNA repertoire and therefore its capacity …
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Mechanisms governing transposable element expression in the Drosophila germ line
… in the germ line, notably including the PIWI-interacting RNA (piRNA) pathway, which acts to repress its targets through both chromatin-mediated silencing and post-transcriptional slicing. The P-element is a classic example of an active transposon that has been highly successful in …
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The organization and evolution of heterochromatin in the Anopheles gambiae complex
… compaction. This study also looks at the Piwi-interacting RNA (piRNA) pathway and its role in An. gambiae. The piRNA pathway is associated with transposable element (TE) suppression in many species, where clusters of vestigial TEs provide some of the RNA necessary for the pathway to …