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Showing 1 to 2 of 2 for “"PITPNC1"”.
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Protein Regulators of Phosphoinositides as Promoters of Cancer Metastasis
… miRNAs, miR-126 and miR- 335. We identify PITPNC1 as amplified in nearly half human breast cancers, and overexpressed in metastatic melanoma, breast, and colon cancer. Biochemical and cellbiological experiments reveal that PITPNC1 binds to phosphatidyl inositol 4-phosphate (PI4P) in the …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… cells. Through coordinate targeting of IGFBP2, PITPNC1 and MERTK, miR-126 inhibits endothelial recruitment, which is required for metastatic angiogenesis and metastatic colonization. IGFBP2 secreted by metastatic cells promotes endothelial recruitment through binding of IGF-1 in the …