Global ETD Search
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Showing 1 to 2 of 2 for “"PIP5Kα"”.
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
… for such a regulatory pathway. We found that PIP5Kα, an isoform of PIP5K, interacts with Nedd4-1, a HECT domain-containing ubiquitin E3 ligase, and undergoes proteasomal degradation via Nedd4-1-mediated polyubiquitination at lysine 88, which leads to reduction in PIP2 levels. Furthermore, we …
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PIP5-Kinase Dependent PIP2 Generation Impairs T Cell Activation by Rigidifying the Actin Cortex
… targeted during T cell activation by APCs. PIP5Kα and γ87 are mainly targeted to the IS, whereas β and γ90 isoforms accumulate at the uropod or distal pole region of the T cells. Overexpression of PIP5Ks caused defective actin polymerization at the periphery of the IS and rigid T cell …