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Showing 1 to 13 of 13 for “"PIM-1"”.
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Strukturbiologie der humanen PIM-1-Kinase
The protein PIM-1 is a serine/threonine kinase which is expressed of the gene pim-1. pim-1 is a proto-oncogene which is implicated in molecular mechanisms of differentiating and proliferation. The cristallography allows to determine the structures of macromolecules. For this the protein kinase …
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Identification and Characterization of a Selective Inhibitor of the PIM-1 Kinase
<p>The PIM-1 kinase is a serine/threonine kinase that has been implicated in the development of many human cancers, including leukemias, lymphomas, and prostate cancer. We have endeavored to identify and characterize a selective inhibitor of the PIM- 1 kinase. Such an inhibitor would have utility …
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Structural Dynamics and Electrostatic Properties of the VEGF and PIM-1 Oncogenic Promoter G-Quadruplexes from Polarizable Molecular Dynamics Simulations
G-Quadruplexes (GQs) are higher ordered nucleic acid structures that form within regions of DNA and RNA that are enriched with guanine nucleobases. These structures are highly stable and have been shown to function in genomic maintenance and regulating key biological processes. Due to their role in …
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Comparison of conventional and super-glassy polymers
… to a microporous, high performance polymer, PIM-1. PIMs are Polymers with Intrinsic Microporosity and were firstly introduced by Budd and McKoewn in the early 2000s. PIM-1 was the first synthesized PIM and, even if many more PIMs followed , PIM-1 shows the most promising gas transport …
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Polymer molecular sieve membranes
… polymers, polymers of intrinsic microporosity (PIMs). Using the PIM-1 polymer as a prototype, we discovered that ultraviolet irradiation of PIM-1 membranes in the presence of oxygen induces oxidative chain scission at the surface, resulting in local densification and structural transformation of …
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Gas Sorption and Swelling in Glassy Polymers - Combining Experiment, Phenomenological Models and Detailed Atomistic Molecular Modeling
… (PI4) und ein neuartiges Polymermaterial (PIM-1), wurden experimentell bezüglich ihrer Sorptions- und Quellungseigenschaften unter CO2- und CH4-Atmosphären bis zu 50 bar charakterisiert. Die Kinetik der Prozesse der experimentell gemessenen Gasaufnahme und Volumendilatation wurde …
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Microporous Polymer-Metal Organic Framework (MOF) Hybrid Materials for Separations
… such as polymers of intrinsic microporosity (PIMs) and metal-organic frameworks (MOFs), have demonstrated performance improvements over conventional polymers. Mixed-matrix membranes (MMMs) have emerged as a potent strategy, combining the processability of polymers with the superior separation …
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Pim Kinase Inhibition: Single Agent and Combination Approaches In B-Cell Lymphoma
… site for Moloney murine leukemia virus (Pim) kinases are Ser/Thr/Tyr kinases. They modulate B-cell development but become oncoproteins and promote cancer development once overexpressed. Containing three isoforms, Pim-1, -2 and -3 are known to phosphorylate various substrates that regulate …
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Leveraging Competitive Sorption in Microporous Polymer Membranes to Enhance Gas Separation Performance
… archetypal polymer of intrinsic microporosity (PIM-1) and its amine-functional analog (PIM-NH₂) to study how enhanced acid-gas (CO₂ and H₂S) sorption brought on by amine functionality positively impacts separation performance. To confirm the generalizability of these trends, competition effects …
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Post-Synthetic Chemical and Morphological Modifications of Polymer Membranes for Gas Separations
… through its application to amine-functionalized PIM-1 and microporous poly(aryl ether) (PAE) polymers. A comprehensive analysis of transport properties, using various permeation and sorption experiments, reveals that FVM is an effective strategy for enhancing gas separation performance and …
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Synthesis and Characterisation of new materials formed from metal-organic frameworks and glasses
… an organic polymer of intrinsic microporosity (PIM), PIM-1. The new materials synthesised by combining MOFs with either inorganic or polymeric glasses are extensively analysed using various techniques and their thermal and mechanical properties are assessed. In particular, focus is centred on …
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Mixed-gas Transport in Microporous Polymer Derivatives for Energy-Efficient Gas Separations
… Polymers of intrinsic microporosity (PIMs) were designed as ultrahigh-free-volume materials with inefficient chain packing and high surface areas, resulting in pure-gas performance beyond that of traditional glassy polymers. Hybrid systems such as mixed-matrix membranes (MMMs) also …
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Graphene based mixed matrix membranes for CO2 separation
L'abstract è presente nell'allegato / the abstract is in the attachment