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Showing 1 to 3 of 3 for “"PIKKs"”.
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Identifying a role for Ciz1 in the DNA damage response
… 3-kinase-like protein kinases (PIKKs), which propagate DDR signalling by phosphorylating SQ/TQ motifs in substrate proteins. Ciz1 is a vertebrate protein previously shown to stimulate DNA replication initiation and facilitate cyclin exchange at pre-replication complexes. Ciz1 …
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A Novel Phosphorylation Site in the Telomeric Protein TRF2 is Regulated by the ATR Kinase and Plays a Role in Relieving Replication Stress at the Telomere
<p>Phosphatidyl inositol 3-kinase-like kinases (PIKKs) have a well documented function at yeast telomeres. Although several lines of evidence suggest that members of the PIKK family also play a role in vertebrate telomere biology, little is known about their specific functions. We report that the …
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Cell cycle checkpoints and checkpoint kinases in the apicomplexan parasites Plasmodium and Toxoplasma
… Phosphatidylinositol 3-kinase-related kinases (PIKKs) are responsible for checkpoint control in model eukaryotes. Members of this protein family are missing in *Plasmodium*, but some remain in the close relative *Toxoplasma gondii*. A suite of experiments were conducted to investigate these …