Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PIAS"”.
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THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
… of 5-HT1A Rs, specifically to determine whether PIAS proteins play a role in the SUMOylation of 5-HT1A Rs. I hypothesize that selective PIAS proteins increase SUMOylation of 5-HT1A Rs. In the first study, I developed a cell culture model to examine the SUMOylation of 5-HT1A Rs. I found that mouse …
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Leishmania Infection and Gut Homeostasis in the Sand Fly Lutzomyia longipalpis.
… The Protein Inhibitor of Activated Stat (PIAS), which plays a major role as a negative regulator of JAK/STAT, and Dual Oxidase (Duox),which plays an important role in infection-induced reactive oxygen species (ROS) generation in insects including sand flies. Quantitative real-time PCR …
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Correlation between pro-inflammatory alleles and clinical and laboratory markers of allergy in Xhosa South Africans
… of potential pro-inflammatory alleles (PIAs), as well as to investigate the relationship between these PIAs and clinical and laboratory markers of asthma and allergic disease. Results: We found several significant associations between several SNPs and allergic disease, specifically in …
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An Examination of the Privacy Impact Assessment as a Vehicle for Privacy Policy Implementation in U.S. Federal Agencies
… agencies implement privacy impact assessments (PIAs) as required under Section 208 of the E-Government Act of 2002. An enhanced understanding of the PIA implementation process serves as a portal into the strategic considerations and management challenges associated with broader privacy policy …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… sumoylated in mammalian cells by members of the PIAS family of proteins and this modification potentiates the repressive activity of Gsc on direct targets such as the Xbra and Gsc promoters, but not on indirect targets such as Mixl1. Taken together, work presented in this thesis describes two …
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The relationships between goal orientation, perfectionism, parental involvement, peer climate, enjoyment, and intention to continue in sport in children.
… The athletes completed the TEOSQ, Sport MPS, PIAS, and the PeerMCYSQ. Parental support and peer task environment was related to girls' and boy's task orientation. For boys, personal standards, parental pressure, and fewer concerns over mistakes, also were related to task orientation. Ego …
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A arte e a arquitetura religiosa popular do Antônio Vicente Mendes Maciel, o Bom Jesus Conselheiro
… atuação como construtor e restaurador de obras pias. Também, quase nada se discutiu sobre os seus seguidores, suas produções culturais tais como: crenças e devoções religiosas, festas, artes plásticas, arquitetura, dentre outras. Sobre o Antônio Vicente Mendes Maciel construtor e restaurador, …
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Methodologies for Systematic Evaluation and Targeted Mitigation of Deficiencies in Critical Machine Learning Models
Despite the growing use of machine learning in healthcare, critical challenges remain unaddressed, models often fail to respond appropriately to life-threatening conditions, exhibit poor generalizability in real-world clinical settings, and show unequal performance across patient subgroups. These …
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Development and testing of thin photocatalyst films
… of a photoinduced absorption spectroscopy (PIAS) setup is described, as well as its use to investigate the photoreduction of oxygen by monitoring the formation and decay of transients associated with photogeneration of electrons in CdS paste films, TiO<sub>2</sub> paste films and …
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Cytokine modulations by type I interferon suppression-negative and NF-κB activation-negative Porcine Reproductive and Respiratory Syndrome Virus
… at position 135 in SAP (SAF-A/B, Acinus, and PIAS) motif is determined as the active residue for IFN suppression. For NF-κB activation, the viral nucleocapsid (N) protein has been found as the effector protein, and the nuclear localization signal (NLS) in N overlaps the NF-κB activation …
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Regulation of the oncogenic PIM1 kinase by SUMOylation
… of the Protein inactivator of activated STATs (PIAS) family could act as E3 SUMO ligases for PIM1. SUMOylated PIM1 showed higher protein kinase activity in vitro when Histone H3.3 was used a substrate, indicating that SUMOylation might enhance PIM1 kinase activity. Interestingly, both K169R and …
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Performance Evaluation of TCP Multihoming for IPV6 Anycast Networks and Proxy Placement
In this thesis, the impact of multihomed clients and multihomed proxy servers on the performance of modern networks is investigated. The network model used in our investigation integrates three main components: the new one-to-any Anycast communication paradigm that facilitates server replication, …