Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"PI3K pathway"”.
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Strategies to Sensitize Bladder Cancer Cells to Small Molecule Inhibitors Targeting The Pi3K Pathway
… of a tumor has become the new paradigm. The PI3K pathway represents an ideal target for bladder cancer, as many of the key proteins of this pathway are altered or mutated in this particular type of cancer. Several small molecule inhibitors have been developed to target this pathway, but their …
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The Design, Synthesis, and Investigation into Small Molecule Modulators of the Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (SHIP)
<p>The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer's disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size and synaptic transmission and plasticity. Neurologic abnormalities such as …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
The Class-IA PI3K signalling pathway regulates key anabolic cellular processes including proliferation, survival, growth and metabolism. Oncogenic hyperactivation of the pathway occurs across tumour types, commonly via genetic alterations in key pathway genes (e.g., *PIK3CA*, *PTEN*). Despite …
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Basis For Targeting Met Activation Mediated Resistance to Pi3K Inhibition In Breast Cancer
… emerging therapies, such as those targeting the PI3K pathway and the MET receptor, has the potential to benefit a significant number of patients with breast cancer. In this study we hypothesized that <strong>concurrent aberrations </strong>in <em>PI3K</em> and <em>MET</em> will render breast …
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Targeting PI3K Isoforms to Improve Effectiveness of T Cells Mediated Immunotherapy
The hyperactivation of the PI3K pathway is associated with immune checkpoint blockade (ICB) resistance in cancer patients, highlighting the potential of combining PI3K inhibitor with ICB. Different PI3K isoforms are suggested to play a role in tumors and T cells, offering an opportunity to …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… manipulation of the phosphoinositide 3-kinase (PI3K) pathway by transgenic knockout of phosphatase and tensin homolog (PTEN) promotes survival and regeneration of murine RGC axons in an optic nerve crush (ONC) model. However, translation issues are yet to be addressed. PI3K converts …
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Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… of the phosphatidylinositol-3 kinase (PI3K) pathway and tumor cell proliferation. To our knowledge, nobody has investigated uptake of NE by other tumor types. In addition, NE has broad substrate specificity suggesting that uptake of NE by tumor cells could impact processes regulating …
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The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
… action, most drugs recruit insulin signaling pathways, which are already impaired in T2DM. Also, compliance and success in achieving sustained improvements in diet or obesity over the long term is marginal. Therefore, an agent that improves diabetes independent of insulin signaling or …
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Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
… in the phosphatidylinositol 3‑kinase (PI3K)/ serine/threonine protein kinase B (AKT) signaling pathway occur frequently in estrogen receptor–positive (ER-positive) breast tumors. Patients with ER-positive, human epidermal growth factor receptor 2–negative (HER2-negative) metastatic …
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Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… promote osteoclastogenesis and osteolysis. The PI3K pathway is activated by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast survival and activity in a CSF-1R dependent manner, we hypothesized that inhibition of CSF-1R or PI3K signaling …
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CONVENIENT ETHERIFICATION USING TRICHLOROACETIMIDATES AND SYNTHESIS OF AMINOSTEROID SHIP INHIBITORS
… cancer progression by influencing cell signaling pathways. There are many studies about how cancer cells coopt cell signaling pathways and use these systems, which control cell growth in normal cells, to facilitate their own uncontrolled progression. One of the major cell signaling pathways …
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VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM
… Akt activation in the phosphoinositide 3-kinase (PI3K) pathway. In the orthotopic intracerebellar tumor model, perifosine significantly increased the survival of treated mice while qualitatively reducing leptomeningeal dissemination. In the flank model, perifosine effectively suppressed the …
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Investigating heterogeneity and mechanisms of resistance in paediatric B-cell non-Hodgkin lymphoma
… cell growth. Furthermore, the PI 3-Kinase (PI3K) pathway was shown to be an important regulator of SP survival by regulating ATP-binding cassette (ABC) transporters hinting towards future therapeutic applications. Due to the rarity of biopsy samples taken at relapse in paediatric B-NHL, …
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Genome-wide cross-cancer analysis reveals the importance of bimodal microRNA in predicting patient survival and drug response
… with poor survival prognosis. Functional pathway analysis revealed that targets of miR-105 and miR-767 were enriched for genes in the phosphoinositide-3-kinase (PI3K) pathway, and a survey of over 200 cancer drugs found that cell lines with high miR-105 and miR-767 levels responded best to …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
… of cell death by upregulating JNK and p38 MAPK pathways, downregulating the ERK1/2 MAPK pathway, and downregulating the PI3K pathway. Western blots confirmed upregulation and downregulation of these pathways by probing for key proteins. Renal cancer cells responded best to infection with …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
… upon loss of PTEN. Upon inhibition of the PI3K pathway, PDGF D/ ?-PDGFR induction was abolished in PTEN-/- cells. Among Akt isoforms, downstream effectors of PI3K, increased Akt3 expression was most prominent in PTEN-/- cells. These results suggest a molecular basis for activation of PDGF …
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
<p>The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical for the promotion of cell growth, division, motility and apoptosis evasion. This signaling axis is therefore commonly targeted in the form of mutations and amplifications in a myriad of …
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Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus
… the intracellular phosphatidylinositol-3-kinase (PI3K) pathway was developed to assess the requirement of this cascade in mediating the acute effects of these hormones and the effects of NPY neurons on body weight and glucose homeostasis.
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Biological activity of palmitoylcarnitine in prostate cancer
… coupled receptors, L-type Ca2+ channels and PI3K pathway. However, it was shown through the use of global gene arrays that lower levels of palcar with uncorrected P value induced many changes in gene expression in PNT1A cells. A comparison with the global changes induced by DHT, an androgen …
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