Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"PI3K isoforms"”.
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Targeting PI3K Isoforms to Improve Effectiveness of T Cells Mediated Immunotherapy
The hyperactivation of the PI3K pathway is associated with immune checkpoint blockade (ICB) resistance in cancer patients, highlighting the potential of combining PI3K inhibitor with ICB. Different PI3K isoforms are suggested to play a role in tumors and T cells, offering an opportunity to …
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Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biological functions in every cell type by generating lipid second messengers. The PI3K family is comprised of multiple isoforms that are divided into three main classes; class I, II and III. All class I …
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Early and late events in NET formation
… affect NET formation (p38, MEK, TAK1, Syk, and PI3K), whether they act early or belatedly. Furthermore, we demonstrate (using epifluorescence microscopy and a pharmacological antagonist) that endogenous mediators released by NETing neutrophils feed back on the cells by engaging a common …
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Pi3K- and Mtor-Dependent Mechanisms of Lapatinib Resistance and Resulting Therapeutic Opportunities
… resistance. We found that activation of PI3K, specifically the p110α catalytic subunit, was enhanced in two out of three LapR cell lines, through p110α activating mutations and/or upregulation. In a third LapR cell line, mTOR activation was enhanced in a manner independent of its usual …
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Regulation of the Lipid Kinase VPS34 by mTOR-Mediated UVRAG Phosphorylation
… data presented here examines a novel PI3KC3 inhibitor that demonstrates profound selectivity over other PI3K isoforms and lipid kinases. This will be important to further examine the functional role of VPS34 and UVRAG.
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… manipulation of the phosphoinositide 3-kinase (PI3K) pathway by transgenic knockout of phosphatase and tensin homolog (PTEN) promotes survival and regeneration of murine RGC axons in an optic nerve crush (ONC) model. However, translation issues are yet to be addressed. PI3K converts …