Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"PI3Kδ"”.
-
PI3Kδ in B cell Homeostasis and Transformation
The lipid kinase phosphoinositide 3-kinase δ (PI3Kδ) is vital for lymphocyte function and development. Hyperactivation of PI3Kδ caused by mutations in PIK3CD drives Activated PI3Kδ Syndrome (APDS), a primary immunodeficiency with increased risk of pulmonary infection, autoimmunity, and B cell …
-
Harnessing synergy between BCL6 and PI3Kδ to generate a new mouse model for lymphoma
… Patients with a gain of function mutation in PI3Kδ, called Activated PI3Kδ syndrome (APDS) commonly develop autoimmunity, lymphoproliferation, and lymphoma. PIK3CD is also among the most commonly mutated genes in Diffuse Large B cell lymphoma (DLBCL). The most commonly studied mouse model of …
-
Actions of Pi3K-Delta Inhibitor, Idelalisib, and Its Combination With Bendamustine In Chronic Lymphocytic Leukemia
… PI3K is a critical node in BCR pathway and PI3Kδ has a pivotal role in B-cell development and maintenance and this isoform is over-expressed in many B-cell malignancies, including CLL.</p> <p>Idelalisib is a FDA approved small molecule PI3Kδ inhibitor. Idelalisib promotes apoptosis in CLL by …
-
FREQUENCY AND AMPLITUDE CONTROL OF CORTICAL OSCILLATIONS BY LIPID METABOLISM
… while PtdIns(3,4)P2 sets the frequency. Class I PI3Kδ is the main functional PI3K involved in regulating the frequency through phosphatase-dependent inhibitory action. Besides, dynamic patterns of global oscillations have been observed on the plasma membrane and the ER membrane coupling with …
-
Investigating the phenotype and function of tissue-resident B cells in mouse and human non-lymphoid organs
… of genetically modified mice with higher (PI3Kδ E1020K-B, Siglec-G-/-) or lower (μMT-) numbers of tissue-resident B cells in NLOs, we tested the function of these cells in the context of urinary tract infection. The number of tissue-resident B cells inversely correlated with bacterial …
-
Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… activation are effective for reduction of cGVHD. PI3Kδ, which is downstream of TCR, co-stimulatory and cytokine signals, is necessary for cGVHD and inhibition can reduce cGHVD in BO and sclerodermatous models. We also show that metabolic pathways for glycolysis, fatty acid synthesis and …
-
A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of …