Global ETD Search

Targeting the AKAP Function of PI3Kγ with a Mimetic Peptide for the Treatment of Obstructive Respiratory Diseases

Ghigo, Alessandra, Murabito, AlessandraUniversità degli Studi di Torino2022

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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD

Lodge, KatharineUniversity of Cambridge2019

… priming agents to enhance the release of NE in a PI3Kγ-dependent manner, with hypoxic supernatants inducing substantial endothelial cell dysfunction and death. To further identify potential histotoxic mediators, I used a proteomics approach to provide a full (and entirely novel) characterisation …

cambridge Repository record for Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD (opens in a new tab)

A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids

Sadiq, Barzan A.University of Cambridge2018

… in the nucleus. In organoids derived from WT, PI3Kγ-null or PTEN-null mouse prostate, application of PI3K-selective inhibitors revealed that PI3Kα had a dominant role in generating PI(3,4,5)P3 in prostate epithelial cells. The levels of PI(3,4)P2 were also elevated substantially in PTEN-null, …

cambridge Repository record for A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids (opens in a new tab)