Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PI3Kβ"”.
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Novel Agonists and Antagonists of Platelet Receptors
… on P2Y12 activation, tromboxane A2 release and PI3Kβ signaling. By screening intermediates in the mevalonate pathway, i.e. the cholesterol synthesis, we found that one of them, farnesyl pyrophosphate (FPP), had an antagonistic effect on ADP induced platelet activation. Further investigation on …
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
… which could be inhibited with a selective PI3Kβ isoform inhibitor and to a lesser degree α isoform inhibitor. These data demonstrate that gAd requires the release of platelet secondary mediators to induce full platelet aggregation and the potentiation of initialaggregation occurs through …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
… models of prostate tumour progression, either PI3Kβ or PI3Ks α and β, have important roles. Furthermore, the cell types and mechanism involved remained unclear. Recent published work in the host laboratory had indicated that there is an unexpectedly large accumulation of PI(3,4)P2 in PTEN-null …