Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PI3Kα"”.
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Rôle de PI3Kα dans la formation du stroma environnant
… pharmacologique et génétique de la PI3Kα dans un modèle murin de PDAC (mutation KRas dans la lignée pancréatique), chez qui la pancréatite a été induite pour accélérer le phénotype, protégeait de l’apparition de lésions néoplasiques et réduisait la fibrose, protégeant ainsi …
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Cardiac PI3Kα Signaling and K+ Channel Regulation in Cardiac Hypertrophy and Heart Failure
… active phosphoinositide-3-kinase-p110α: caPI3Kα), were utilized. Electrophysiological experiments revealed that repolarizing K<super>+</super> current amplitudes were increased and K<super>+</super> current densities were normalized in hypertrophied ventricular myocytes from swim-trained or …
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and this thesis is dedicated to investigating how specific protein-ligand interactions in the active site affect selectivity and affinity of inhibitors; how ATP-competitive inhibitors affect membrane …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
… of PI3K-selective inhibitors revealed that PI3Kα had a dominant role in generating PI(3,4,5)P3 in prostate epithelial cells. The levels of PI(3,4)P2 were also elevated substantially in PTEN-null, compared to WT prostate organoids, use of PI3K-selective inhibitors suggested that it was also …