Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"PI3K/Akt signalling pathway"”.
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The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration
The PI3K-Akt signalling pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that …
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SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer
The PI3K-Akt signalling pathway is central to cell proliferation and growth, and hyperactivating mutations in this pathway are found in a large number of cancers. Downstream of PI3K, Akt is heavily studied, however the highly related SGK family of protein kinases have recently been identified as …
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
… anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway to modulate cell proliferation, cell cycle progression and cell survival. Sphingosine kinase 1 (SphK1), a known tumour promoter/oncogene, has been shown to activate the PI3K/Akt pathway to enhance resistance to …
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Perineural Invasion in Oral Squamous Cell Carcinoma and Salivary Gland Malignancies: Incidence, Prognostic Impact and Molecular Insight
… as being possibly of importance in PNI. The PI3K/Akt signalling pathway is a well-established driver of cancer progression, however, the mechanism of NGF-induced Akt phosphorylation remains unclear. Identifying the molecular background of PNI-driven OSCC and SGMs will shed light on the …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of …