Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"PI3K/Akt signaling"”.
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An Investigation of the Role of Insulin Deficiency and Loss of PI3K-Akt Signaling Downstream Regulators GSK3β -CREB Signaling in the Pathogenesis of the Diabetic Brain
… is speculated to act through activation of PI3K-Akt signaling. We hypothesized that the neurodegenerative changes and cognitive impairments observed in the chronic type 1 DM brain occur through impaired insulin-mediated phosphorylation of CREB/GSK3β, critical neuronal signals downstream of …
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Gsk3 Mediates Signaling Upstream of Akt
The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …
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Effects of Rosemary Extract and Rosemary Extract Polyphenols on Skeletal Muscle Insulin Resistance
… through the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway. Impaired PI3K/Akt signaling is associated with skeletal muscle insulin resistance (IR), leading to chronically elevated blood glucose levels followed by a compensatory rise in insulin levels. Rosemary extract increases …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… Foxo3 and Foxo4. Conditional inactivation of PI3K/Akt pathway components in the male germ line confirmed that PI3K signaling regulates Foxo1 stability and subcellular localization, revealing that the Foxos are crucial effectors of PI3K/Akt signaling in SSCs. The nuclear localization of Foxo1, …
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Molecular analysis of insulin action using high throughput genetic screens
… glucose uptake as a result of defects in insulin signaling and attenuated GLUT4 translocation. Elucidating the molecular causes underlying insulin resistance is important for the development of therapeutics for this disease. Identifying the components involved in the propagation or regulation of …
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Small Molecule Regulator of ENTPD5, and ER Enzyme in the PTEN/AKT Pathway
PI3K signaling plays a crucial role in effecting alterations in a broad range of cellular functions in response to diverse extracellular stimuli (insulin, growth factors, integrins and GPCRs etc.). A key downstream effector of PI3K is the serine-threonine kinase Akt, which in response to PI3K …
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The Regulation of Bone Marrow Mesenchymal Stem Cells by Vascular Cell Adhesion Molecule-1
… impacts BM MSC survival by mediating PI3k/Akt signaling. Furthermore, Vcam1-null MSCs display enhanced osteolineage capacity. Surprisingly, VCAM1 loss and associated MSC death did not affect BM HSCs. Single-cell RNA-sequencing of pooled BM and compact bone sorted stromal cells revealed …
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Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer
… I then examined the regulatory effects of PI3K/AKT signaling on E-cadherin and DSG2 expression in metastatic prostate cancer cell lines. The expression of activated AKT was found to be associated with the inhibition of E-cadherin expression, while the expression of DSG2 was relatively …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… risk for developing AD. Indeed, insulin signaling is altered in post-mortem brain tissue from AD patients and insulin and treatments known to enhance insulin signaling, can improve cognitive function. Furthermore, clinical evidence has shown that AD patients and mouse models of AD often …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… the response of the skin to UV. EGFR-dependent signaling increased keratinocyte proliferation, suppressed mitochondrial-mediated apoptosis, and accelerated epidermal hyperplasia in response to UV. Abrogation of EGFR blocked the UV-induced activation of mitogen activated protein kinases (MAPK) …
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Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation
… proliferation, and to decipher the intracellular signaling mechanisms employed by these growth factors to regulate cell proliferation. Pilot studies established effective concentrations for each growth factor on a bovine trophoblast cell line (CT1). The first set of studies examined how each …
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The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… skeletal muscle and liver by inhibiting insulin signaling transduction. Interleukin-1 receptor-associated kinase-1 (IRAK-1) is a serine/threonine kinase functioning in Toll-like Receptor signaling pathways, and plays an important role in inflammation and immune response. In our studies, we …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… to 14-3-3σ downregulation, thereby activates PI3K/Akt signaling pathway and degrades p53, and further inhibits TGF-β induced p21 expression and cell cytostatic function. In addition, we found that overexpression of 14-3-3ζ promotes TGF-β induced breast cancer cells bone metastatic colonization …
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Investigating metabolic and mitochondrial adaptations triggered by blood flow during the endothelial-to-hematopoietic transition
… protein analyses indicate that force-responsive PI3K-Akt signaling regulates mTORC1 effectors S6K and 4E-BP1 to promote translation of mitochondrial ribosomes and electron transport chain proteins.</p> <p>Our work exposes an overlooked role of force in the maturation of mitochondrial machinery …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
… of FXR, and instead involved activation of PI3K/AKT signaling. Finally, vitamins A and D were found to activate nuclear receptors in the intestine and repress bile acid synthesis. These results underscore the role of nuclear receptors and their ligands in maintaining intestinal homeostasis …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
… WT1 gene via the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway in the leukemic cell line K562. Given our finding that WT1 downregulated the expression of IRF-8, we propose that WT1 is a link between BCR/ABL1 and IRF-8. This provide a mechanistic explanation for BCR/ABL1 induced …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
<p>Akt (also known as protein kinase B) serves a central regulator in PI3K/Akt signaling pathways to regulate numerous physiological functions including cell proliferation, survival and metabolism. Akt activation requires the binding of Akt to phospholipid PIP3 on the plasma membrane and subsequent …
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
… controls PIP3 levels thereby inhibiting the PI3K/AKT signaling, a pathway implicated in various lymphatic disorders. Our studies confirm this inhibitory role of SHIP2 against PI3K/AKT in lymphatic endothelial cells, and identify SHIP2 as a potential regulator of MAPK/ERK signaling, another …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… proliferation and cell death, and cellular signaling pathways in response to both extracellular and intracellular stimuli control it. The data presented in this dissertation are aimed at understanding regulatory links between the endocrine and immune systems, focusing on how proinflammatory …
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Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis
… of controlling cell growth. Additionally, PI3K-Akt is a cell survival pathway that is aberrantly expressed in cervical cancer cells. This pathway has a profound role in inhibiting mitochondrial intrinsic apoptotic signaling pathway. Advanced stage cervical cancer is difficult to treat and …
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