Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PI3K/Akt/mTOR signaling pathway"”.
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… fundamentally attributable to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying …
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The mechanism of ovarian cancer chemoresistance
… (EMT), cancer stem cells (CSC), as well as the PI3K/Akt/mTOR signalling pathway in OC chemoresistance, and provides a range of potential candidate chemoresistant biomarkers with proteomic technologies. The aims of this study were to: 1) compare the expression differences of EMT, CSC and …
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Nuclear PTEN Regulates Thymidylate Biosynthesis and Cellular Sensitivity to Antifolate Treatment
… of metabolic processes through antagonizing the PI3K/AKT/mTORC1 pathway. However, the metabolic regulation of PTEN in the nucleus remain undefined. Using a gain-of-function approach to examine the metabolic consequences of PTEN targeted to different sub-cellular compartments in human prostate …