Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 394 for “"PI3K"”.
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
<p>The phosphatidylinositol-3-kinase (PI3K) signaling pathway is activated in 20-40% colorectal cancers (CRC) through PTEN loss (PTEN<sup>loss</sup>) and <em>PIK3CA</em> mutations (<em>PIK3CA</em><sup>mut</sup>). Allosteric AKT inhibition with MK2206 monotherapy has been ineffective in CRC …
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying PI3K/AKT/mTOR …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
Background The PI3K/AKT/mTOR pathway is an intracellular signaling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Aim of our …
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Targeting PI3K Isoforms to Improve Effectiveness of T Cells Mediated Immunotherapy
The hyperactivation of the PI3K pathway is associated with immune checkpoint blockade (ICB) resistance in cancer patients, highlighting the potential of combining PI3K inhibitor with ICB. Different PI3K isoforms are suggested to play a role in tumors and T cells, offering an opportunity to …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
The Class-IA PI3K signalling pathway regulates key anabolic cellular processes including proliferation, survival, growth and metabolism. Oncogenic hyperactivation of the pathway occurs across tumour types, commonly via genetic alterations in key pathway genes (e.g., *PIK3CA*, *PTEN*). Despite …
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SYNTHESIS AND SCREENING OF PI3K INHIBITOR PRODRUGS FOR TREATMENT OF PROSTATE CANCER
… prostate cancer. Phosphoinositide 3-kinases (PI3Ks) are involved in several imperative cellular functions such as growth and survival; therefore, inhibition of PI3K induces apoptosis (programmed cell death) and suppresses tumor growth. Several compounds have been identified as PI3K inhibitors, …
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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… remnant liver. Phosphatidylinositol 3-kinase (PI3K), composed of a p85ƒÑ regulatory and a p110ƒÑ catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in liver regeneration has not been clearly delineated. In these studies, …
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Pi3K- and Mtor-Dependent Mechanisms of Lapatinib Resistance and Resulting Therapeutic Opportunities
… resistance. We found that activation of PI3K, specifically the p110α catalytic subunit, was enhanced in two out of three LapR cell lines, through p110α activating mutations and/or upregulation. In a third LapR cell line, mTOR activation was enhanced in a manner independent of its usual …
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Direct Effects of Metformin On Pi3K and Ras Signaling In Endometrial Cancer
… metformin’s effect on cell proliferation, PI3K and Ras-MAPK signaling, and apoptosis. A xenograft mouse model was also used to evaluate the effects of metformin treatment on <em>in vivo</em> tumor growth. These preliminary studies demonstrated that K-Ras mutant cell lines exhibited a …
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… (Y) 768, 955, and/or 969 and that Shp2 and PI3K work cooperatively to promote FLT3-ITD-induced leukemogenesis. Consistently, mutation of N51-FLT3 tyrosine 768 to phenylalanine reduced proliferation and levels of phospho-Erk compared to N51-FLT3-expressing cells while having no effect on …
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Die Hemmung der PI3K verstärkt die Kontraktilität in alpha1-adrenerg stimuliertem Myokard
… demonstriert, dass Phosphoinositide 3-Kinasen (PI3K) eine grundsätzliche Rolle in der Regulierung myocardialer Kontraktilität spielen. Jedoch, auch wenn bekannt ist, dass es unter alpha1-adrenerger Stimulation zu einer PI3K Aktivierung kommt, ist der Einfluss der PI3K nach alpha1-adrenergen …
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Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… transition is dictated by B-cell adapter for PI3K (BCAP). Mice harboring a macrophage specific deletion of BCAP fail to recover from and succumb to DSS-induced colitis due to prolonged intestinal inflammation and impaired tissue repair. Following microbial stimulation, gene expression in WT …
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a crucial regulator of cell survival, is associated with poor outcome in neuroblastomas and our lab¡¦s previous work has shown that GRPR regulates the expression of PI3K/Akt pathway components. However, the signaling mechanisms …
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Basis For Targeting Met Activation Mediated Resistance to Pi3K Inhibition In Breast Cancer
… emerging therapies, such as those targeting the PI3K pathway and the MET receptor, has the potential to benefit a significant number of patients with breast cancer. In this study we hypothesized that <strong>concurrent aberrations </strong>in <em>PI3K</em> and <em>MET</em> will render breast …
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SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer
The PI3K-Akt signalling pathway is central to cell proliferation and growth, and hyperactivating mutations in this pathway are found in a large number of cancers. Downstream of PI3K, Akt is heavily studied, however the highly related SGK family of protein kinases have recently been identified as …
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Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection
… screen revealed phosphoinositide 3-kinase (PI3K) as a central player transducing ACM-mediated neuroprotection. To identify additional proteins contributing to the protective activity, endogenous neuronal PI3K was immunoprecipitated from astrocytes exposed to ACM or control media, and MS/MS …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
… to limit infarct size,potentially through the PI3K signaling pathway. However, the exact signaling pathway of this protection still remains elusive.
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Strategies to Sensitize Bladder Cancer Cells to Small Molecule Inhibitors Targeting The Pi3K Pathway
… of a tumor has become the new paradigm. The PI3K pathway represents an ideal target for bladder cancer, as many of the key proteins of this pathway are altered or mutated in this particular type of cancer. Several small molecule inhibitors have been developed to target this pathway, but their …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… target of rapamycin (PI3K/mTOR) signaling pathway can be used to predict patient outcome in cohorts containing patients with various subtypes of soft tissue sarcoma. Furthermore, we have previously shown that high levels of phosphorylated AKT correlate to poorer …
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