Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"PI31"”.
-
A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health
… the necessity for the proteasome regulator, DmPI31, in neuronal maintenance and show that dietary restriction and NAD+ repletion, can regulate both DmPI31 and proteasome activity. Generation of dmPI31 mutant clones in the Drosophila eye show rapid degeneration of photoreceptor cells and RNAi …
-
STRUCTURAL AND FUNCTIONAL STUDIES OF F-BOX-ONLY PROTEIN FBXO7 AND ITS INTERACTIONS WITH PROTEASOME INHIBITOR PI31
… protein partners, such as proteasome inhibitor PI31. The best known biological function of Fbxo7 is its role as the substrate-recognition subunit of the SCFFbxo7 (Skp1-Cul1-F-box protein) E3 ubiquitin ligase that catalyzes the ubiquitination of hepatoma up-regulated protein (HURP) and inhibitor …
-
The proteasome and its ancillary proteins
… proteins or cofactors. Finally, I focused on PI31, a poorly characterised protein that has been described as a proteasome inhibitor. Indeed, by adding purified PI31 to 20S proteasomes I showed that in the presence of PI31 the proteasome peptidase activities are decreased. Interestingly, …
-
Post-translational control of mitochondria by Fbxo7 in Parkinson's disease
… between Fbxo7 and its binding partner PI31. Fibroblasts carrying this mutation were also found to have reduced levels of mitochondrial respiration, increased ROS and increased sensitivity to oxidative and proteasomal stress. Fibroblasts with an N-terminal truncating S93X mutation were …
-
The discovery of a role of FBXO7/PARK15 in intracellular trafficking
… to synapses via the proteasome regulator PI31, but a direct link between Fbxo7 and intracellular trafficking remains to be uncovered. We identified over 30 trafficking proteins in a substrate screen for SCFFbxo7 ubiquitination, including the Dynein regulators Lis1 and Nde1. I validated …
-
Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… Nutcracker physical interactors, we isolated DmPI31. Nutcracker promotes DmPI31 stability, and a complex between these proteins is essential for both caspase activation and sperm differentiation. DmPI31 is conserved with the mammalian PI31 proteins, initially described as proteasome inhibitors. …