Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PI3-K"”.
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Kardioprotektion durch Postkonditionierung gesunder Rattenherzen sowie von Herzen mit kardiovaskulären Risikofaktoren: Charakterisierung der Signaltransduktion unter besonderer Betrachtung von PI3-K/Akt, mTOR, ERK1/2 und GSK-3ß
… Untersuchungen belegen, dass hierbei die PI3-Kinase ein wichtiges Signaltransduktionselement ist, da einerseits durch die Inhibition der PI3-Kinase mittels Wortmannin die Infarktgrößenreduktion vollständig aufgehoben war und andererseits nach einer 1,5-minütigen Reperfusion eine vermehrte …
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Characterisation of Anti-Apoptotic Signalling Pathways in Hepatocytes activated by alpha-Lipoic Acid and Atrial Natriuretic Peptide
… In fact, the LA-mediated activation of the PI3-K/Akt survival pathway seemed to be responsible for the antiapoptotic properties of alpha-lipoic acid. Consequently, incubation with a specific PI3-K-inhibitor significantly reduced both, R-LA-mediated decrease in caspase activity and …
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Rutas de señalización intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata
… survival pathways Duch as RAS/RAF/MAP-kinases, PI3-K/PKB, as well as death pathways, stress-activated MAP-kinases (JUN-kinases and p38).
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Regulation der myokardialen Glukoseaufnahme : Mechanismen bei alpha-adrenerger Stimulation und die Rolle der AMP-aktivierten Proteinkinase bei Ischämie
… die Rolle der Phosphatidyl-Inositol-3-Kinase (PI3-K) und der Herzleistung bei alpha-adrenerger Stimulation überprüft, und es wurde die Rolle der AMP-aktivierten Proteinkinase (AMPK) in einem transgenen Mausmodell ohne AMPK-Funktion (AMPK-KD-Maus) bei Ischämie und Reperfusion untersucht. …
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Investigation of Interleukin 1B synthesis and secretion by dendritic cells: Interplay between toll-like receptor and FCG receptor
… IL-1I? production and secretion by moDCs, whilst PI3-K and p38 MAPK as negative modulators.
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Induction of Heme Oxygenase By a Carbon Monoxide-Releasing Molecule
… between 12 and 20 hours. Inhibition of MAPK, PI3-K, JNK pathways showed no changes in HO-1 expression. Likewise inhibition of cGMP, a known pathway for CO, had no effect on protein expression suggesting that HO-1 expression by CORM-2 works by an alternate pathway. In conclusion the ability of …
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p38 MAPK Signalling in Endothelial Apoptosis
… Interestingly, p38 signalling inhibited the PI3-K/Akt survival pathway and the phosphorylation of Bad. Results from a phosphatase assay showed that doxorubicin-induced p38 activity in endothelial cells could maintain PP2A activity at a normal level and thereby prevents phosphorylation of Akt …
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Estrogenic modulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses
… mechanisms - ERα-mediated LTP involves PI3-K signalling whereas GPER1-mediated LTP involves ERK signalling and transactivation of EGFR. Further, ERα, GPER1 and hippocampal-synthesised E2 have been implicated in the induction of activity-dependent LTP at TA-CA1 synapses highlighting the …
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Characterisation of Novel Rab5 Effector Proteins in the Endocytic Pathway
… PI(3)P a complex network of effectors, including PI3-Kinase (PI3-K), the FYVE-finger proteins EEA1 and Rabenosyn-5 that functionally cooperate in membrane transport. Moreover, Rab5 regulates endocytosis from the apical and basolateral plasma membrane in polarised epithelial cells. During my PhD …
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Ein neuer und ungewöhnlicher Signalweg erlaubt physiologischen Konzentrationen von Erythropoetin mitogene Kinasen in primären erythroiden Vorläuferzellen zu aktivieren
… der Familie der Phosphatidylinositol-3-Kinasen (PI3K), PI3Kg, nach Stimulation mit einer physiologischen Konzentration von Epo aktiviert werden. Überraschenderweise kann in PEPs die Epo-induzierte Ras-, MEK- und Erk-Aktivierung durch drei strukturell unterschiedliche PI3K-Inhibitoren blockiert …
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Akt signal transduction dysfunction in the 3xTg-AD mouse model of Alzheimer's disease
… (IR, IGF-1R) are the primary activators of PI3- K/Akt through which they regulate cell growth, development, glucose metabolism, and learning and memory. Work in our lab and others shows increased Akt activity and phosphorylation of its downstream targets in AD brain, along with insulin and …