Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"PI3 kinase/Akt"”.
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Nephrin und CD2AP aktivieren den PI3-Kinase/AKT-Signalweg im Podozyten
… mit p85, der regulatorischen Untereinheit der PI3-Kinase, interagieren. <br>Die Interaktion von Nephrin und p85 ist Phospho-Tyrosin-abhängig und kann durch Genistein, das die Phosphorylierung des intrazellulären Nephrin-Abschnittes hemmt, aufgehoben werden. <br>Nephrin und CD2AP induzieren …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
PINK1 (PTEN-induced putative kinase-1) functions as a ubiquitous serine-threonine kinase, with pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis …
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Einfluss der Überexpression des zellulären Prionproteins auf ischämisch induzierte neuronale Schädigung in vivo
… die ischämische Regulation der zelltodrelevanten PI3-Kinase/Akt und MAPK/Erk-Signalkaskaden untersucht werden. In den durchgeführten Experimenten zeigten die TG35-Mäuse signifikant geringere Infarktvolumina und hatten eine reduzierte postischämische Erk1/2-Phosphorylierung. Die PrP-Überexpression …
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Investigating the function of PINK1 in cancer development and pathogenesis
PTEN‐induced kinase 1 (PINK1) was identified initially in cancer cells as a gene up‐regulated by overexpression of the central tumour suppressor, PTEN. Loss‐of‐function mutations in PINK1 were discovered subsequently to cause autosomal recessive Parkinsonʹs disease (ARPD). Despite much research …
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Kardioprotektion durch Postkonditionierung gesunder Rattenherzen sowie von Herzen mit kardiovaskulären Risikofaktoren: Charakterisierung der Signaltransduktion unter besonderer Betrachtung von PI3-K/Akt, mTOR, ERK1/2 und GSK-3ß
… Untersuchungen belegen, dass hierbei die PI3-Kinase ein wichtiges Signaltransduktionselement ist, da einerseits durch die Inhibition der PI3-Kinase mittels Wortmannin die Infarktgrößenreduktion vollständig aufgehoben war und andererseits nach einer 1,5-minütigen Reperfusion eine vermehrte …
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Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… VEGF, upon activating their respective tyrosine kinase receptors, can engage the PI3-kinase/Akt, MAPK, and PLC-γ/PKC pathways. Thus, crosstalk between VEGF and insulin signaling may occur at numerous points. Our objectives were twofold: 1) to characterize the combined effects of insulin and VEGF …
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Physiological Effects of Estradiol in the Mouse Hippocampal Formation
… estradiol activation of two of these candidates, PI3 kinase/Akt and brain-derived neurotrophic factor (BDNF), in the dorsal hippocampus of female mice. In naturally cycling and ovariectomized female mice, estradiol increased hippocampal Akt and BDNF signaling as determined by immunocytochemistry …
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Ligand Bias by the Endogenous Agonists of CCR7
… are regulated by the G-protein coupled Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here …
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Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
… underlying these events. We found that a PI3 kinase/Akt inhibitor suppressed the generation of TEMs in culture in response to M-CSF. Further, we found that HIF-1¿¿ and M-CSF synergistically act to regulate the generation of TEMs. These studies highlight the role of TEM modulation in tumor …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… death. On the other hand, inhibition of the IRS/PI3 kinase/Akt signaling pathway was reported to be critical in FFA-induced beta cell apoptosis (Lingohr et al, 2003; Wrede et al, 2002). Recently, endoplasmic reticulum (ER) stress was postulated to be a critical mediator of FFA-induced beta cell …