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Showing 1 to 20 of 45 for “"PI3 kinase"”.

  1. Nephrin und CD2AP aktivieren den PI3-Kinase/AKT-Signalweg im Podozyten

    Hartleben, Björn

    … mit p85, der regulatorischen Untereinheit der PI3-Kinase, interagieren. <br>Die Interaktion von Nephrin und p85 ist Phospho-Tyrosin-abhängig und kann durch Genistein, das die Phosphorylierung des intrazellulären Nephrin-Abschnittes hemmt, aufgehoben werden. <br>Nephrin und CD2AP induzieren …

    freiburg-diss Repository record

  2. The PI3-Kinase/TSC Pathway: A Role in Neural and Renal Development and Pathology

    Zhou, Jing2010

    … and its protein product negatively regulates the PI3K/AKT pathway through counteracting the kinase function of PI3-Kinase. Loss of function of PTEN results in overactivation of AKT and in turn activates multiple AKT downstream pathways. One AKT substrate is the TSC1/2 protein complex, which …

    utswmed Repository record

  3. Characterising the effects of ACK-mediated phosphorylation on the Class IA PI3-Kinase regulatory isoforms

    Hodder, SamanthaUniversity of Cambridge2025

    Activated Cdc42-associated kinase (ACK), a non-receptor tyrosine (Tyr) kinase, was the first effector discovered for the small GTPase Cdc42. ACK is emerging as an important feature of the cancer landscape and thus, is a promising potential target for the treatment of many malignancies. ACK …

    cambridge Repository record

  4. Einfluss des Insulin-ähnlichen Wachstumsfaktors I auf die Androgenrezeptor-Signaltransduktion in Prostatakrebszellen

    Schmidt, SiwTechnische Universität Dresden

    … dieser Arbeit deuten auf einen, durch den PI3-Kinase-Signalweg vermittelten, proteasomalen Abbauprozess des Rezeptors hin. Da die Suppression der downstream gelegenen Proteinkinase Akt keine Veränderung hinsichtlich der Degradation aufwies, konzentrierte sich die weiterführende Arbeit auf …

    qucosa-diss

  5. Kardioprotektion durch Postkonditionierung gesunder Rattenherzen sowie von Herzen mit kardiovaskulären Risikofaktoren: Charakterisierung der Signaltransduktion unter besonderer Betrachtung von PI3-K/Akt, mTOR, ERK1/2 und GSK-3ß

    Wagner, Claudia KarinTechnische Universität Dresden

    … Untersuchungen belegen, dass hierbei die PI3-Kinase ein wichtiges Signaltransduktionselement ist, da einerseits durch die Inhibition der PI3-Kinase mittels Wortmannin die Infarktgrößenreduktion vollständig aufgehoben war und andererseits nach einer 1,5-minütigen Reperfusion eine vermehrte …

    qucosa-diss

  6. Dissection of CD2AP functions in epithelial cells

    Wang, YuouUniversity of Illinois at Urbana-Champaign2020

    … phenocopy those generated by inhibiting PI3 Kinase. I confirmed that blocking PI3 Kinase activity led to a decrease in cell height. I therefore tested if there was a molecular, mechanistic connection between CD2AP and PI3 Kinase in controlling epithelial cell height. Immunofluorescence …

    uiuc Repository record

  7. The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN

    Shen, Zhirong2011

    PI3 Kinase and PTEN lipid phosphatase control the level of cellular phosphatidylinositol (3,4,5)-trisphosphate, an activator of AKT kinase that promotes cell growth and survival. Mutations activating AKT are commonly observed in human cancers. Activation of AKT and downstream PI3 Kinase signaling …

    utswmed Repository record

  8. Investigating the function of PINK1 in cancer development and pathogenesis

    O'Flanagan, CiaraUniversity College Cork2013

    PTEN‐induced kinase 1 (PINK1) was identified initially in cancer cells as a gene up‐regulated by overexpression of the central tumour suppressor, PTEN. Loss‐of‐function mutations in PINK1 were discovered subsequently to cause autosomal recessive Parkinsonʹs disease (ARPD). Despite much research …

    cork Repository record

  9. Investigating the mechanisms by which PINK1 protects against Parkinson's disease

    Furlong, RachelUniversity College Cork2019

    PINK1 (PTEN-induced putative kinase-1) functions as a ubiquitous serine-threonine kinase, with pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis …

    cork Repository record

  10. The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells

    Mansley, Morag K.University of Dundee2010

    … circuit current (Ieq). Selective inhibition of PI3-kinase, mTORC2 and SGK1 left ~80 % of the current intact, indicating these signalling molecules are not required for basal Na+ transport. Acute addition of insulin stimulated Ieq and this occurred with a concomitant increase in mTORC2, SGK1 and …

    dundee Repository record

  11. Einfluss der Überexpression des zellulären Prionproteins auf ischämisch induzierte neuronale Schädigung in vivo

    Müller, Tilo2012

    … die ischämische Regulation der zelltodrelevanten PI3-Kinase/Akt und MAPK/Erk-Signalkaskaden untersucht werden. In den durchgeführten Experimenten zeigten die TG35-Mäuse signifikant geringere Infarktvolumina und hatten eine reduzierte postischämische Erk1/2-Phosphorylierung. Die PrP-Überexpression …

    goettingen Repository record

  12. Charakterisierung der funktionalen Rolle von Cytohesin-1 in der LFA-1-vermittelten T-Zell-Adhäsion

    Geiger, ChristianeLudwig-Maximilians-Universität

    … selbst. Es konnte gezeigt werden, daß PI3-Kinase in die Kontrolle der Cytohesin-1-Funktion involviert war. Die Überexpression einer konstitutiv aktiven Form dieser Kinase (P110*) führte zu einer gesteigerten Adhäsion von Jurkat E6-Zellen an ICAM-1. Eine Inkubation dieser Zellen mit dem …

    lmu-germany Repository record

  13. Cofilin

    Lee, Kyeong-HeeUniversität Würzburg

    … the capacity to bind cytoskeletal actin in vivo. PI3-kinase inhibitors block both the dephosphorylation of cofilin and its association with the actin cytoskeleton. Importantly, cofilin, actin, PI3-kinase and one of its substrates, namely phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) which …

    wurz-thes Repository record

  14. Ligand Bias by the Endogenous Agonists of CCR7

    Zidar, David Alexander2009

    … are regulated by the G-protein coupled Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here …

    duke Repository record

  15. Role of downstream signal transduction molecules of congenital middle ear cholesteatoma according to its site of origin

    조, 민정2011

    … bind to their receptors and activate tyrosine kinases in the plasma membrane. This study was aim to anayze clinical characteristics according to the site of origin and to investigate the distribution of EGFR, PDGFR, PLC-γ1, and PI3 kinase in human congenital middle ear cholesteatoma. This study …

    ajou Repository record

  16. The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration

    Islam, Mohammad RafiqulUniversity of Dundee2015

    The PI3K-Akt signalling pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that …

    dundee Repository record

  17. Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation

    Bashour, Keenan T.2013

    … activating human T cells is developed. The Src kinase Lck, though predominantly cytosolic, is an ideal candidate for the coupling of the TCR and CD28 pathways. Membrane associations bring Lck in contact with these receptors, where mediation of its active state by kinase activity and regulation …

    columbia-diss Repository record

  18. CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION

    Manne, Bhanu KanthTemple University. Libraries2015

    … was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is inhibited. PP2 abolished phosphorylation of Syk and Phospholipase Cγ−2. Fucoidan-induced platelet activation had a lag phase, which is reminiscent of platelet activation by collagen and CLEC-2 receptor …

    temple Repository record

  19. Inflammation and neutrophil recruitment in ageing subjects and patients with chronic obstructive pulmonary disease

    Sapey, ElizabethUniversity of Birmingham2010

    … biological samples. Treating COPD cells with a PI3 Kinase inhibitor differentially altered their migration, reducing speed but increasing accuracy, so that cells now resembled those from controls.

    birmingham Repository record

  20. Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin

    Wang, Amanda CyphersVirginia Tech2008

    … VEGF, upon activating their respective tyrosine kinase receptors, can engage the PI3-kinase/Akt, MAPK, and PLC-γ/PKC pathways. Thus, crosstalk between VEGF and insulin signaling may occur at numerous points. Our objectives were twofold: 1) to characterize the combined effects of insulin and VEGF …

    vt Repository record

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