Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"PI 3-kinase"”.
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Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… thesis demonstrate that phosphatidylinositol 3 '-kinase (PI 3- kinase) associates with a novel serine kinase that can phosphorylate IRS-1 and reduce its ability to act as a substrate for insulin and interferon alpha (IFNalpha) receptors. PI 3-kinase is shown to associate with a wortmannin …
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
… and IL-4 is phosphatidylinositol 3$\sp\prime$-kinase, a lipid kinase which phosphorylates phosphatidylinositol on its 3$\sp\prime$ carbon. We demonstrate that activation of this enzyme is critical for IGF-I- and IL-4-mediated inhibition of apoptosis in CSF-deprived myeloid progenitor cells. …
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Cellular Mechanisms Involved in Reactive Carbonyl and Hyperinsulinemia Enhancement of Diabetic Complications
… survival of serum deprived B-cells through a PI 3-kinase and JNK pathway. We describe a mechanism where rapamycin sensitive serine/threonine-proline phosphorylation of IRS-2 reduces IL-4/IRS-2/PI 3-kinase dependent reduction of TNF-alpha receptor (TNF-R1). Finally, we show that the circulating …
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Untersuchungen zur Signaltransduktion des CXCR4 (CD 184) Chemokinrezeptors im Hinblick auf Vitalität und Migration humaner B-CLL-Zellen
… für das Chemokin SDF-1. Dieser Chemokinrezeptor spielt eine Schlüsselrolle für das Homing ins Knochenmark und die Stroma-vermittelte Apoptose-Resistenz. Stromazellen des Knochenmarks und Ammenzellen („nurse-like cells“, NLC) sezernieren konstitutiv SDF-1(CXCL 12). <br>Ziel der vorliegenden Arbeit …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… an antiobesity agent; plant-derived compounds (pinitol and chamaemeloside) and agents known to affect insulin sensitivity, e.g. metformin, tolbutamide, thiazolidinediones, vanadyl sulphate and thioctic acid. Models used for investigation included the L6 skeletal muscle cell line and isolated …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… the presence of RA. IGF-I-induced activation of PI 3-kinase is responsible for this enhancement of differentiation and prevention of apoptosis. IGF-I also promotes vitamin D$\sb3$-induced macrophage differentiation via acting through its own receptor. Indeed, IGF-I is a critical element in serum …
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Role of Laminins in the Development of the Peripheral Nervous System
… cells exhibit reduced phosphatidylinositol 3-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin peptide into mutant sciatic nerves partially restores PI 3-kinase activity and reduces apoptotic signals. In a Schwann cell/dorsal root ganglion …
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A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins
Class I phosphoinositide (PI) 3-kinases exert profound effects on cell growth, division, motility and metabolism via their primary lipid product phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3) and a metabolite of this, phosphatidylinositol 3,4- bisphosphate (PtdIns(3,4)P2). Many …
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Effects of Zinc on the Insulin Receptor and Insulin Signal Transduction Pathway
… transport induced by zinc or insulin. The PI 3-kinase inhibitor, wortmannin decreased basal glucose transport and blocked zinc-stimulated glucose transport. H7, an inhibitor of PKC, did not reduce basal glucose transport but decreased zinc-induced glucose transport in a dose-dependent …
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Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum
… was used to inhibit the actin cytoskeleton and PI (3) kinases in the parasite. In this study Cytochalasin D and Latrunculin A, which depolymerise and prevent actin fimalment formation, Jasplakinolide, which stabilises actin filaments, and Wormannin and LY294002, which inhibit PI 93) kinase, were …
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Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survival
… chemo-resistant cancer cells are addicted to keeping low cAMP in PDE4 regulated compartments, and modulation of this pool causes G1/S-phase arrest and apoptosis. I also show that PDE4 controlled cAMP negatively regulates the PI 3-Kinase/Akt pathway, which some cells are addicted to for survival. …
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X-Box Binding Protein-1 is Important in Maintenance of Endothelial Integrity and Migration
… protein production through the VEGF receptor 2 / PI-3-kinase pathway. Knockdown of XBP1 by shRNA lentiviral transfection ablated disturbed flow-induced HDAC3 upregulation. Similarly to HDACS, overexpression of XBPlu by adenoviral gene transfer increased Akt phosphorylation at serine 473 and haem …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
… (also called PKB) is a 63 kDa serine/threonine kinase involved in promotion of cell survival, proliferation a nd metabolic responses downstream the phosphoinositide-3-kinase (PI 3-kinase) signaling pathway. In resting cells, Akt is a predominantly cytosolic enzyme; however generation of PI …
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Effects of phosphatidylinositol on ApoA-I metabolism: Implications in HDL metabolism
… be inversely associated with the risk of developing CHD. Naturally occurring phospholipids such as phosphatidylinositol (PI), have been shown to increase plasma apoA-I levels and HDL levels in animal models and human subjects; but the mechanism remains to be elucidated. Since in humans, HDL is …
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α-Lipoic Acid Attenuates Ischemia Reperfusion Injury of the Rat Liver
… describes for the first time that the protein kinase Akt plays a crucial role in IRI. The cytoprotective kinase was activated by LA preconditioning during ischemia and reperfusion. Blocking Akt activation by simultaneous application of wortmannin, a selective PI-3 kinase inhibitor, abrogated …
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The effects of Low α-Linolenic fatty acid Soybean Oil and Mid Oleic acid Soybean Oil on the growth of Her-2/neu and Fatty acid synthase over-expressing human breast cancer (SK-Br3) cells
… needs to be investigated. Increased human epithelial growth factor receptor 2 (Her-2/neu) and fatty acid synthase (FAS) are associated with BC progression. In fact, FAS activity and expression are affected by dietary FA composition and FA metabolism. Hypothesis of this research is that LLSO …
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Tissue Transglutaminase And Its Role In Human Cancer Progression
… of Ras and Cdc42, lead to the activation of PI 3-kinase and NF[kappa]B, mediating the EGF-dependent up-regulation of tTG in breast cancer cells. Moreover, overexpression of wild-type tTG in these cancer cells, but not its enzymatically-defective counterpart, fully mimics the actions of EGF. …
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Measurement and Analysis of Calcium-Dependent Exocytosis in Giant Excised Membrane Patches
… non-SG fusion is ATP-dependent and blocked by PI-kinase inhibitors, wortmannin and adenosine, the dependency is not neutralized by the PI(3)-kinase inhibitor LY294002, PI(4,5)P2 ligands, such as neomycin, a PI-transfer protein that can remove PI from membranes, and PI(4,5)P2, PI(3)P and PI(4)P …
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