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Showing 1 to 20 of 26 for “"PI(4,5)P2"”.

  1. Functional analysis of Nt-Hypo1 and NtPLC3, two novel pollen-specific proteins from Nicotiana tabacum

    Helling, DianaUniversität Heidelberg

    … Erforschung der Prozesse dar, die pflanzliches Spitzenwachstum steuern oder regulieren. Pollenschläuche sind longitudinale Zellen, die äußerst schnell und zielgerichtet durch das weibliche Blütengewebe wachsen und der Übertragung männlicher Geschlechtszellen in die Samenanlage und somit der …

    heid-diss Repository record

  2. Molecular mechanisms of Sorting nexin-9 in membrane triggered actin polymerisation

    Vaishnav, PanktiUniversity of Cambridge2024

    … in a rare disease of phospho- inositide lipid metabolism, Lowe syndrome. It’s multifaceted nature is attributed to its structure. The SH3-PX-BAR domains of SNX9 are able to integrate inter- actions with phosphatidylinositol phosphates (PIPs) at membranes, and membrane curvature sensing to …

    cambridge Repository record

  3. Distinct roles of PI4P 5-kinase isoforms in polar tip growth of pollen tubes

    Ischebeck, Till2012

    Das Phospholipid Phosphatidylinositol-4,5-bisphosphat (PI(4,5)P2) kommt in wachsenden Pollenschläuchen vorwiegend in der apikalen Plasmamembran der Spitze vor. Welche Enzyme PI(4,5)P2 an dieser Stelle synthetisieren und welche Funktionen dieses Signallipid hat, war bislang unbekannt. Daher wurden …

    goettingen Repository record

  4. Regulatory and Gating Mechanisms of TMEM16A Chloride Channel

    Le, Son Cong2021

    … Ca2+-dependent ion channels and phospholipid scramblases. The TMEM16A and TMEM16B CaCCs conduct Cl- across the membrane and regulate transepithelial fluid transport, smooth muscle contraction, neuronal excitability and sensory signal transduction. Most other TMEM16 members are scramblases …

    duke Repository record

  5. TORC2 and Eisosomes Are Spatially Interdependent, Requiring Optimal Level of Pi(4,5)P<sub>2</sub> for Their Integrity

    Bartlett, Katelyn Rae

    … this study, I reveal that the eisosome organizer Pil1 colocalizes with the MCT marker Avo2. Furthermore, I provide evidence that the formation of MCT is dependent on both eisosome integrity and adequate levels of the plasma membrane phosphoinositide PI(4,5)P2. Taken together, my findings indicate …

    mo-state Repository record

  6. Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation

    김, 보경2011

    Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], mainly produced by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, …

    ajou Repository record

  7. Protein Regulators of Phosphoinositides as Promoters of Cancer Metastasis

    Sengelaub, Caitlin Anne

    … tumors. However, the molecular mechanisms underpinning this multistep progression are poorly defined. Successful metastasis requires a cancer cell to acquire multiple capabilities, including the ability to migrate, invade, and co-opt the microenvironment in the distal organ for colonization. …

    rockefeller Repository record

  8. Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1

    Cheong, Fei YingUniversität Heidelberg

    Phosphoinositides are key lipid signaling molecules present in membranes of all eukaryotes. Different species of phosphoinositides serve as membrane signposts at distinct cellular compartments. This assymetric distribution of phosphoinositides is achieved by the presence of an elaborate set of …

    heid-diss Repository record

  9. Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension

    Fagbola, Emmanuel2023

    … and the presence of phosphoinositide (PI) species in specific intracellular compartments. Pulmonary arterial hypertension (PAH) is a disease characterized by lung vascular obstruction, endothelial dysfunction, and heterozygous germline mutations in BMPR2, which encodes the bone …

    queens Repository record

  10. The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling

    Kielkowska, Anna JadwigaUniversity of Cambridge2018

    … Dissertation title: The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular …

    cambridge Repository record

  11. Measurement and Analysis of Calcium-Dependent Exocytosis in Giant Excised Membrane Patches

    Wang, Tzu-Ming2010

    … non-SG fusion is ATP-dependent and blocked by PI-kinase inhibitors, wortmannin and adenosine, the dependency is not neutralized by the PI(3)-kinase inhibitor LY294002, PI(4,5)P2 ligands, such as neomycin, a PI-transfer protein that can remove PI from membranes, and PI(4,5)P2, PI(3)P and PI(4)P …

    utswmed Repository record

  12. A Role for the Phosphoinositide Lipid Kinase PI4KIIIbeta in Breast Oncogenesis and Akt Activation

    Morrow, AnneUniversité d'Ottawa / University of Ottawa2014

    The lipid kinase phosphatidylinositol 4-kinase III β (PI4KIIIβ) phosphorylates phosphatidylinositol (PtdIns) to generate PI(4)P in the Golgi. PI4KIIIβ is likely involved in the development of breast cancer as it has been reported genetically amplified in a subset of human breast tumours and is a …

    ottawa-retro Repository record

  13. Synaptojanin1 is involved in endolysosomal trafficking in cone photoreceptors

    George, Ashley Amelia2015

    … membranes from the outer segment; the retinal pigment epithelium phagocytoses outer segment discs. Therefore the focus on outer segment trafficking has resulted in a deficit in our understanding of the process of protein degradation in photoreceptor cells. In this study we establish that the …

    washington Repository record

  14. Evaluating Phosphatidylinositide as Lipid Biomarkers for Hyperglycemia-related Triple-negative Breast Cancer Aggressiveness

    Kile, Aaron2025

    … options and poor patient outcomes. Clinical and epidemiological studies suggest that systemic metabolic conditions, particularly high blood glucose associated with Type 2 Diabetes, may worsen TNBC progression. However, there are no current biomarker for detecting TNBC, especially in hyperglycemic …

    iupui Repository record

  15. Self-assembly of filopodia-like structures on supported lipid bilayers

    Lee, KwonmooMassachusetts Institute of Technology2010

    … by applying frog egg extracts to supported lipid bilayers containing phosphatidylinositol(4,5)bisphosphate, PI(4,5)P 2. The FLSs recapitulate important characteristics of filopodia - they assemble parallel actin bundles from the lipid membrane and they form in the presence of capping activity. …

    mit Repository record

  16. Trpv5: Structure, Function And Drug Discovery

    Hughes, Taylor2019

    … (CaM) and the abundant plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) which act as an inhibitor and activator, respectively. By solving the structures of TRPV5 in the presence of these modulators as well as TRPV5 in an apo state we clearly identified the binding …

    penn Repository record

  17. Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress

    Chen, Mark2010

    Of the total amount of phospholipids in the cell, phosphoinositides account for only a small fraction, yet they play an indispensable role in regulating cellular homeostasis. The phosphatidylinositol derivative, PI(4,5)P2 (PIP2)is an essential mediator of cellular processes such as signal …

    utswmed Repository record

  18. The localisation and regulation of phosphatidylinositol-4-phosphate 5-Kinase gamma splice variants and the discovery of a new mammalian splice variant, PIP5KIγ_v6

    Xia, YangUniversity of Cambridge2011

    Type I PIP kinases (phosphatidylinositol 4-phosphate 5-kinases, PIP5Ks) catalyse the majority of cellular synthesis of PI(4,5)P2. To date, three mammalian isoforms (r1, r2, r3) have been found. PIP5KIr is subject to complex C-terminal splice variation, enhancing its transcriptional diversity …

    cambridge Repository record

  19. Comparative analysis of membrane-associated signatures at mutualistic and pathogenic plant-microbe interfaces

    Guyon, AlexanderUniversity of Cambridge2024

    … membranes. My thesis identifies protein and lipid signatures of these interface membranes and explores their roles in interface establishment, maintenance, and the outcomes of plant-microbe interactions. I selected eight candidate genes in Nicotiana benthamiana that were transcriptionally …

    cambridge Repository record

  20. Role of Bacterial Effectors SopD and SopB in Pathogenicity of Salmonella enterica serovar Typhimurium.

    Bakowski, Malina A.2010

    … dynamics during S. Typhimurium invasion of epithelial cells. SopD promotes membrane sealing and macropinosome formation, events that may have important consequences for efficiency of bacterial cell entry in vivo. Furthermore, we demonstrate that SopD is recruited to the invasion site …

    toronto-retro Repository record

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