Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"PI(4"”.
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… enriched in phosphatidylinositol 4 phosphate [PI(4)P] and that the clathrin adaptor AP-1 binds PI(4)P directly, suggesting that PI(4)P binding may specify the TGN-specific recruitment in conjunction with Arf1. My studies showed that another monomeric clathrin adaptor GGA also binds PI(4)P and …
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Bit error simulation of FSK, BPSK, and pi/4 DQPSK in flat and frequency-selective fading mobile radio channels using two-ray and measurement- based impulse response models
… FSK, BPSK, and Ï /4 DQPSK with Nyquist pulse shaping in indoor and outdoor, flat and frequency-selective fading channels. The BER performance of Ï / 4 DQPSK using the data rate and the pulse shaping requirement in the U.S. Digital Cellular Standard are studied. BER results for high data rate (> …
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Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1
Phosphoinositides are key lipid signaling molecules present in membranes of all eukaryotes. Different species of phosphoinositides serve as membrane signposts at distinct cellular compartments. This assymetric distribution of phosphoinositides is achieved by the presence of an elaborate set of …
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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
… signalling. Phosphatidylinositol-4-phosphate (PI(4)P) has been shown to regulate Smo activation. We determined that the fatty-acid side chains of the phosphatidylinositols interact with Smo CRD, and PI(4)P specifically enhances activator induced Hh signalling. Therefore, we speculated that …
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A Role for the Phosphoinositide Lipid Kinase PI4KIIIbeta in Breast Oncogenesis and Akt Activation
The lipid kinase phosphatidylinositol 4-kinase III β (PI4KIIIβ) phosphorylates phosphatidylinositol (PtdIns) to generate PI(4)P in the Golgi. PI4KIIIβ is likely involved in the development of breast cancer as it has been reported genetically amplified in a subset of human breast tumours and is a …
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Molecular mechanisms of exosome secretion
… conversion of phosphatidylinositol-3-phosphate (PI(3)P) to phosphatidylinositol-4-phosphate (PI(4)P) catalyzed by Myotubularin 1 (MTM1) and phosphatidylinositol 4-kinase type IIα (PI4KIIα) on the surface of MVEs mediates the recruitment of the exocyst complex. The exocyst then targets the MVEs to …
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Novel regulators of trafficking in the yeast Golgi-endosomal system
… that phosphatidylinositol 4-phosphate (PI(4)P) generated by the PI(4)-kinase Pik1p plays an essential role in maintenance of Golgi secretory function and morphology. Up to now relatively few targets of Pik1/PI(4)P signaling at the Golgi have been identified and it thus remains elusive …
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THE OPTIMIZATION OF A TIME-RESOLVED, VESICLE-BASED FLUORESCENCE ASSAY FOR THE ACTIVITY OF THE LIPID KINASE PI4K-IIIBETA AND THE EFFECT OF LIPID TRANSFER PROTEINS ON ENZYME ACTIVITY
Human PI4K-IIIβ is an 89 kDa phosphatidylinositol (PI) kinase that phosphorylates its substrate headgroup at position C-4, thus producing PI(4)P. This phosphoinositide is the most abundant in the trans-Golgi network where it is essential for secretory vesicle formation, as well as the precursor for …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… Golgi-localised Arf1 and its downstream effector PI(4)KIIIß, were responsible for localised generation of the lipid PI(4)P on Trans-Golgi network vesicles, which are involved in mitochondrial division. Indeed, silencing of both genes led to a drastic mitochondrial hyperfusion, accompanied by …
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Charakterisierung der Rolle und Funktion der Protein-Tyrosin-Phosphatase Meg2
… der endogenen Meg2-Aktivität nach Immunpräzipitation und in vitro Phosphatasetests zeigen eine erhöhte Phosphataseaktivität nach Stimulation von Zellen mit FCS, EGF und LPA, wogegen TPA stark inhibierenden wirkt. Aktivitätsstudien mit GST-Meg2-Fusionsproteinen zeigen, dass die CRALBP-Domäne …
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The K- pi pi system in the reaction K-p -> K-pi+pi-p at 5.5 BeV/c
… As a part. of this experiment a study of the Kpipi system in the reaction K-pi -> K-pi+pi-p at 5.5 BeV/c has been carried out to The following results are obtained in this study (l) Evidence that the Deck mechanism plays a dominant ·'*0 role in K (890) production. leading to a broad enhancement …
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Deep learning-based anomaly detection for edge-layer devices
… Set, are deployed and tested on the Raspberry Pi 4. Model performance metrics, including fit and evaluation time across various batch and data sizes, are compared alongside those of identical models running on higher-capacity devices. Device resource metrics of CPU and Memory usage are …
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Synaptojanin1 is involved in endolysosomal trafficking in cone photoreceptors
… membranes from the outer segment; the retinal pigment epithelium phagocytoses outer segment discs. Therefore the focus on outer segment trafficking has resulted in a deficit in our understanding of the process of protein degradation in photoreceptor cells. In this study we establish that the …
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Desplegar l'eina "Zeek IDS" i la seva posterior explotació per a l'anàlisi d'activitats sospitoses a la xarxa
… la implantació de Zeek IDS en una Raspberry Pi 4 i la instal·lació d'ELK Stack en un servidor virtual Ubuntu Server, a més de la creació de quatre dashboards de seguretat. Mitjançant unes proves de funcionament, es demostra que la instal·lació d'un IDS conjuntament amb ELK, eleva …
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Functions of Phosphatidylinositol 4-Phosphate 5 Kinases in Actin Cytoskeletal Regulation During Phagocytosis
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is a crucial signaling phosphoinositide at the plasma membrane (PM) which mediates a variety of biochemical activities and cellular functions. It is primarily synthesized by type I phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) through the …
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Nonlinear gyrokinetic simulations of intrinsic rotation in up-down asymmetric tokamaks
… generated by effects that are formally small in [pi]* =- [pi]i / a, the ratio of the ion gyroradius to the tokamak minor radius. These effects are insufficient in anticipated reactors because [pi]*, will be significantly smaller. Recent theoretical work concludes that up-down asymmetry in the …
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PoT: bridging IoT with phone technology
… PoT presents a seamless user experience by capitalizing on ubiquitous phone network infrastructure while promoting context-aware telephony solutions. Using open-source technologies, PoT ensures affordability, interoperability, scalability, and security. A tangible PoT prototype is developed …
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Closed Loop Analysis of Space Systems (CLASS) a modular test system for small satellite verification and validation
… dynamics simulations executing on a Raspberry Pi 4. The satellite attitude dynamics, orbital mechanics, and space environment properties are computed by the CLASS software reliably and rapidly. It has the ability to interface with the satellite’s flight computer, sensors, and actuators. If …
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Measurement and Analysis of Calcium-Dependent Exocytosis in Giant Excised Membrane Patches
… non-SG fusion is ATP-dependent and blocked by PI-kinase inhibitors, wortmannin and adenosine, the dependency is not neutralized by the PI(3)-kinase inhibitor LY294002, PI(4,5)P2 ligands, such as neomycin, a PI-transfer protein that can remove PI from membranes, and PI(4,5)P2, PI(3)P and PI(4)P …
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Lightweight intrusion detection of attacks on the Internet of Things (IoT) in critical infrastructures.
… CICIDS2017) on both Windows and Raspberry Pi 4 platforms demonstrated impressive performance. The OCFSDA model achieved high overall accuracy (99% and 97% on respective datasets) with significantly reduced execution times (0.30s and 0.12s) and memory usage (2KB). Moreover, the model …
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