Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"PI(3,4)P2"”.
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The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling
… Dissertation title: The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of …
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Role of trans-Golgi network vesicles in mitochondrial fusion
… the set of phosphatidylinositol phosphate (PIP) species as potential regulators of mitochondrial morphology uncovered the localization of phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P2] in close proximity to the mitochondrial network. PI(3,4)P2 is produced by Class II …
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A Role for the Phosphoinositide Lipid Kinase PI4KIIIbeta in Breast Oncogenesis and Akt Activation
The lipid kinase phosphatidylinositol 4-kinase III β (PI4KIIIβ) phosphorylates phosphatidylinositol (PtdIns) to generate PI(4)P in the Golgi. PI4KIIIβ is likely involved in the development of breast cancer as it has been reported genetically amplified in a subset of human breast tumours and is a …
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Molecular mechanisms of Sorting nexin-9 in membrane triggered actin polymerisation
… in a rare disease of phospho- inositide lipid metabolism, Lowe syndrome. It’s multifaceted nature is attributed to its structure. The SH3-PX-BAR domains of SNX9 are able to integrate inter- actions with phosphatidylinositol phosphates (PIPs) at membranes, and membrane curvature sensing to …
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The Design, Synthesis, and Investigation into Small Molecule Modulators of the Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (SHIP)
<p>The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer's disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 …
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
… upregulated in metastastic cells, while an epithelial isoform, Menalla, is downregulated. SH2- domain containing 5-inositol phosphatase (SHIP2) interacts with Mena and is thought to play a role in breast cancer. SHIP2 is a 5-phosphatase that catalyzes the dephosphorylation of …
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DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS
Phosphatidylinositol(3,4,5)trisphosphate (PI(3,4,5)P3 or PIP3) is the lipid product and key signalling output of Class I phosphoinositide 3-kinases (PI3Ks) and acts as a coordinator of a huge network that controls cellular processes such as metabolism, cell growth and movement. Mutations that …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Lipids and proteins are two major components of cells, which are crucial for structural integrity and maintenance of cellular homeostasis by integrating various extracellular and intracellular cues. Lipids are involved in the regulation of cellular functions and can interact with proteins and …