Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"PHOSPHO-PROTEOMICS"”.
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Post-translational phosphorylation dynamics in Arabidopsis and Physcomitrella
Phosphorylation is the most abundant post-translational modification that involves the chemical addition of a phosphate group onto serine, threonine, or tyrosine residues of substrate proteins. Phosphorylation is utilized to regulate protein activity, stability, or localization to respond to …
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A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
… unmasked by cell cycle lengthening. Nuclear phospho-proteomics studies (ongoing) revealed that Palbociclib treatment rewires kinase signaling in the nucleus and chromatin-associated phosphorylation networks, setting the ground for the discovery of mechanistic insights into how cell cycle …
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Characterization of the Zebrafish Panx1a Phosphorylation Profile and Interactome in the Regulation of the Channel Function and Trafficking
… of the channel while maintaining a focus on the phospho-proteomics and the kinase-dependent signaling involving Panx1. We identified a critical residue highly conserved in the third transmembrane domain, Y205 of the zebrafish Panx1a protein, which plays a role in the stabilization of the protein, …
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Developmental trajectory of synaptic vesicle recycling in wild type and neurodevelopmental disorder mqodels
… also investigated in Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (Dyrk1A) heterozygous (HET) neurons, which model DYRK1A syndrome, another monogenic NDD that is highly associated with ASD, intellectual disability and epilepsy. DYRK1A is located in the Down syndrome critical …
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Statistical methods to infer kinase activities and kinase-substrate interactions using phosphoproteomic data
… an important role during cell signalling. They phosphorylate proteins to regulate their interactions, structural conformation, cell location and enzymatic activation. Mass Spectrometry (MS) based phosphorylation studies (i.e. phosphoproteomics) has revolutionized the study of kinase signalling, …