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Showing 1 to 6 of 6 for “"PHGDH"”.

  1. The role of phosphoglycerate dehydrogenase in cell proliferation and tumor progression

    Mattaini, Katherine R. (Katherine Ruth)Massachusetts Institute of Technology2015

    … proliferation. Phosphoglycerate dehydrogenase (PHGDH) catalyzes the first step in the serine biosynthesis pathway, and the gene encoding this enzyme is amplified in human cancer. PHGDH-amplified cells depend on PHGDH expression to proliferate, and upon PHGDH knockdown, supplying exogenous serine …

    mit Repository record

  2. Abrogation of serine metabolism exacerbates intestinal epithelial inflammation via C/EBPβ-NF-κB pathway

    Yang, GuangChristian-Albrechts-Universität zu Kiel

    … enzyme phosphoglycerate dehydrogenase (PHGDH), maintains celular redox balance. Serine metabolism is upregulated in cancer and immune cells, supporting survival and growth. Our previous study showed ER stress mediated rewiring of serine metabolism was a key molecular feature in IBD. …

    cau-kiel Repository record

  3. Defining sources of nutrient limitation for tumors

    Sullivan, Mark Robert.Massachusetts Institute of Technology2019

    … pathway enzyme phosphoglycerate dehydrogenase (PHGDH).

    mit Repository record

  4. The relationship between docohexanoic acid (DHA) and L-serine, providing an insight into the biochemistry of meningioma

    Hatchell, HayleyUniversity of Central Lancashire2017

    … 2 (PKM2) and phosphoglycerate dehydrogenase (PHGDH) were shown. Therefore, the results demonstrated that within meningioma tissues, serine can allosterically regulate the flux through glycolysis. The association that serine presence alone can alter the metabolic flux was demonstrated in the …

    cent-lancashire Repository record

  5. Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power

    Miao, Shucheng, <p>https://orcid.org/0000-0002-7306-0966</p>2022

    … spheroids viability. The effect of PHGDH inhibitor CBR5884, GLS inhibitors CB839, and GCLC inhibitor was enhanced with TRIM24 knock-down, indicating that TRIM24 plays a critical role in oxidation-reduction (REDOX)-related cell survival.</p> <p>Here, with metabolomic studies, we …

    uthsc Repository record

  6. TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER

    Zhu, Yan, <p>https://orcid.org/0000-0002-3347-3045</p>2024

    … pathway, including the known regulators PHGDH and PSAT1. Knockdown of PSAT1 was sufficient to replicate synergy with single agent inhibition of either BET or mTOR. Our results tied together epigenetic regulation, metabolism, and apoptosis induction as key therapeutic targets for further …

    uthsc Repository record