Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"PHENOTHIAZINES"”.
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… chemical perturbants of the autophagic process. Phenothiazines emerged as the largest family of drugs that alter the autophagic process by increasing LC3-II punctae levels in different cancer cell lines. In addition, we observed multiple biological effects in cancer cells treated with …
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Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics
… clinically approved non-antibiotics including phenothiazines hold promise as novel classes of therapeutics in other indications. However, in addition to inherent neuroleptic properties, phenothiazines and related antipsychotics elicit adverse side effects at clinically relevant doses thus …
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Αντιμικροβιακή δράση φαινοθειαζινικών παραγώγων (χλωροπρομαζίνης-προμεθαζίνης)
… examines the in vitro antibacterial action of phenothiazines choropromazine and promethazine in gram positive and gram negative bacteria and their interaction with antibiotics.
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A Study of the Interaction of Copper with Selected Psychotropic Compounds
… amines" (central nervous stimulants) and the phenothiazines (neuroleptics and major tranquillizers) began after noting several tenuously joined observations. The former class of compounds when administered in excess can produce varying symptoms from acute anxiety, (ephedrine) to a toxic …
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ΕΠΙΔΡΑΣΗ ΤΩΝ ΑΜΙΝΩΝ ΣΤΙΣ ΔΟΜΙΚΕΣ ΚΑΙ ΚΑΤΑΛΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΤΗΣ ΓΛΥΚΟΓΟΝΙΚΗΣ ΦΩΣΦΟΡΥΛΑΣΗΣ Β
… THE AMINES STUDIED ARE THE ALIPHATIC AMINES, THE PHENOTHIAZINES AND THE POLYMYXINS. THESE AMINES IN THE PRESENCE OF AMP INDUCE A SIGNIFICANT ENHANCEMENT OF ENZYME ACTIVITY. THE BINDING CENTER OF PHOSPHORYLASE B FOR AMINES IS POSSIBLY LOCATED ON THE N-TERMINAL CHAIN OF PHOSPHORYLASE B. FROM ALL …
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The molecular structures of chlorpromazine and thiethylperazine and a discussion of the action mechanism of the phenothiazine derivatives
… and of mental diseases in general. Although the phenothiazines have been subjected to extensive clinical tests, their chemical structural features have not so far been found to have a sufficiently constant association with pharmacological, psychological and clinical effects to develop a theory of …
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The effect of tranquilizing agents on diadochokinetic movement in a senile psychotic population
… is the effect of tranquilizers, specifically phenothiazines , on diadochokinetic movement in a geriatric population? It was hypothesized that patients exhibiting overt effects of long term phenothiazine therapy (dyskinesia ) would show a reduced rate of diadochokinetic movement when compared …
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Comparative Biochemistry of Drug-Binding Proteins in Calmodulin/S100 Family
… studies presented in this thesis, we have used phenothiazines as tools to probe the relationships between structural domains and functional domains in calmodulin. The approach to the problem of structure-function relationships can be framed in three questions: Do other calciurn modulated …
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Synthesis and electrochemistry of photoantimicrobial agents based on the azine chromophore
… by oxidation of the appropriate precursor phenothiazines by iodine and were characterised for synthetic purposes by infrared spectroscopy, nuclear magnetic resonance, ultravioletvisible spectroscopy, mass spectrometry and thin layer chromatographic techniques. The ability of the …
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Tyrosine-Specific Protein Phosphorylation in Cells Transformed by Rous Sarcoma Virus or Stimulated by Mitogens
… reaction since it is inhibited by phenothiazines. A partial purification procedure for the 42K protein was devised. This procedure is currently being used to obtain sufficient antigen for the purpose of raising specific antisera, reagents that will be invaluable to further …
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The characterization of pharmacokinetic properties and evaluation of in vitro drug combination efficacies of novel antimalarial compounds
… Selected amino artemisinins and redox active phenothiazines, phenoxazines, thiosemicarbazones, and quinolone derivatives were screened for antimalarial activity and mammalian toxicity. These were found to be potently active (11 μM) to Chinese Hamster ovarian (CHO) cells. The compounds are thus …
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Targeting Tau Aggregation for the Diagnosis and Treatment of Alzheimer’s Disease
… aggregation include non-cyclic carbocyanines, phenothiazines, triarylmethines, and rhodanines. A study of these compound families reveals polarizability as the key molecular characteristic for generating inhibitory potency. Further analysis with the most potent non-cyclic cyanine revealed the …
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Application of natural dyes in textile industry and the treatment of dye solutions using electrolytic techniques
Anodic oxidation of a commercial dye, methylene blue (MB), from aqueous solutions using an electrochemical cell is reported. Data are provided on the effects of eight different types of supporting electrolytes, concentration of electrolytes, initial dye concentration, current and electrolytic time …
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New methodologies and approaches to reaction discovery in transition metal catalysis
… nitrogen heterocycles, including carbazole, phenothiazines, and tetrahydroquinoline. The utility of this methodology is highlighted by the one-pot synthesis of a member of the pyrrolophenanthridone class of alkaloid natural products. In another set of studies, a new approach to the use of …