Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PHARMACOLOGICAL SCIENCES"”.
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… 1999 and a review article published in Trends in Pharmacological Sciences (publication 1) in 1997 are also included. In the initial work (publication 2) to investigate if it was possible to correlate in vitro activity with in vivo efficacy for PDE4 inhibitors structurally diverse compounds were …
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Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, …
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Vascular receptor changes in ischemic stroke
The present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating …
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Translating Foreign Ideas into Domestic Practices : Pharmaceutical Policies in Laos and Vietnam
Similar policies may be found in different countries. This, in turn, is an indication that policies travel. But why are certain policies imitated while others are not? The author seeks to further our understanding of policy diffusion and its dynamics by investigating how foreign ideas are …
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Distribution and function of TRP ion channels in primary sensory neurons
… channel in the vascular system and provide novel pharmacological tools for investigating the role of this ion channel. Whether activation of TRPA1 in the vascular system explains the beneficial antihypertensive effect observed by garlic treatment remains to be shown. This study also expands our …
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ΣΥΝΘΕΣΗ ΚΑΙ ΦΑΡΜΑΚΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΜΕΡΙΚΩΝ ΥΠΟΚΑΤΕΣΤΗΜΕΝΩΝ 2'-ΥΔΡΟΞΥ- ΑΙΘΥΛ-ΑΜΙΝΟ'Η ΔΙΑΜΙΝΟ-ΒΟΥΤΥΡΟ-ΚΕΤΟΝΩΝ ΜΕ ΒΙΟΛΟΓΙΚΟ ΕΝΔΙΑΦΕΡΟΝ
A NUMBER OF NEW Γ-(2'-HYDROXY-)-AMINO-KETONES ARE SYNTHESIZED AND THE IMPORTANCE OF VARIOUS EFFECTS ON THE FORMATION OF THE CLOSED, (N,O),(N,N) SYSTEM IS STUDIED. IONIZATION CONSTANTS (PKA'S) AND PARTITION COEFFICIENTS (N-OCTANOL-W OF THE SYNTHESIZED COMPOUNDS ARE DETERMINED EXPERIMENTALLY AND …