Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"PGK1"”.
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Phosphoglycerate kinase 1 as a therapeutic target in motor neuron disease
… to disease pathology. Phosphoglycerate kinase 1 (PGK1) is a key enzyme in the first ATP-producing step in the glycolysis pathway. PGK1 may have multiple other roles in cells apart from its role in glycolysis but these are less well understood, and the consequences of increased PGK1 activity in …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… of aerobic glycolysis related genes (GLUT1, PGK1 and PDK1), and the rate of glucose uptake in those cells. HIF 1α was highly expressed in SNU216, and the responsiveness of SNU216 to 5-FU was lower than it of MKN45. The expressions of glucose transporter 1(GLUT1), phospho-glycerate …
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Linkage studies of x-linked cleft palate and ankyloglossia in a British Columbia native kindred
… Recombination was observed between CPX and PGK1 (Zmax = 7.63 at recombination fraction [θ̂̂̂] = 0.03) and between CPX and DXYS1 (Zmax = 5.59 at θ =0.04). These results localize B.C. CPX between PGK1 and DXYS1 in the Xq13.3-q21.31 region.
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Metabolic engineering of industrial yeast strains to minimize the production of ethyl carbamate in grape and Sake wine
… gene under the control of the S. cerevisiae PGK1 promoter and terminator signals into the URA3 locus of the Sake yeast strains K7 and K9. The ‘self-cloned’ strains K7EC- and K9EC- produced Sake wine with 68% less EC. The Sake strains K7EC- and K9EC- did not efficiently reduce EC in Chardonnay …
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The Effects of Metronomic and Maximum-Tolerated Dose Chemotherapy in Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy and mRNA Expression
… with MET presented higher Hif-1a, Aldoa and Pgk1 expression, indicating increased glycolytic activity. Taken together, this work highlights that the opportunities and challenges of MET to treat CRC can be better understood by using combined modalities that complement the information of …
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Stemness status in differentiated and undifferentiated glioma cells
… glycosylase (UDG), Phosphoglycerate kinase 1 (PGK1), Heterogeneous nuclear riboprotein K (HNRNPK) and moesin that can be used as differentiated markers for glioma cells. Vimentin, Eukaryotic translation initiation factor 4e (EIF4e), Casein kinase II alpha 1 (CSNK2A1) should be further …
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Structure and Function Studies on tRNA Splicing Endonuclease
… and normalization of band intensity to the Pgk1 protein. In the course of my work, I have identified new information about how eukaryote-specific residues and domains of multiple TSEN subunits contribute to the proper function of their corresponding protein. I have also found that altering …
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Revelation of new properties of pro-apoptotic human proteins, Bax and α-synuclein, using baker's yeast
… were sub-cloned downstream of the constitutive PGK1 promoter (expression from which can occur in the presence of both glucose and galactose), on an episomal vector, and were co-expressed with a chromosomally-integrated Bax gene expression cassette driven by the GAL1 promoter (which is …