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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"PGF"”.
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Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast
<p>Placenta growth factor (PGF) expression is downregulated in preeclampsia (PE), a leading cause of maternal morbidity and mortality. The pathophysiology of PE is thought to be manifested by a poorly perfused placenta hampered by hypoxic stress. Two stress-mediate angiogenic responses include …
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Lutalyse® induces uterine-ovarian PGF₂α release in sheep: a critical component of induced luteolysis
Exogenous PGF<sub>2α</sub>, (see Appendix I for definitions of abbreviations) is luteolytic in midluteal (1.e., d 9 of a 17 d estrous cycle) sheep. However, the pharmacokinetic responses to PGF<sub>2α</sub>-induced luteolysis are not known. This study (Exp. 1 and 2) was conducted to determine …
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Factors That Enhance Pituitary and Ovarian Functions in Postpartum Beef Cows (Naloxane, Gn-Rh, Pgf(2), Indomethacin)
Currently and for several years ahead of it becomes ideal that each beef cow should produce one calf every year in order to sustain an economically viable cow-calf operation. In actual farm settings, however, this ideal condition is seldom achieved because of a variety of factors that act singly or …
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Impacts of Placental Growth Factor Deficiency and of Preeclampsia on Brain Development and Function
… angiokine “placental growth factor” (PGF). Offspring of PE (PE-F1) compared to uncomplicated pregnancies have higher risks for hypertension, cognitive impairment, and stroke. However, mechanisms explaining these risks are poorly understood. This thesis aimed to explore the mechanistic …
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Effect of 6α-methyl-17α hydroxyprogesterone acetate on uterine secretion of prostaglandin (PG) F₂α and luteal sensitivity to exogenous PGF₂α
… acetate (MPA) reduces uterine secretion of PGF₂α, but it does not interfere with luteolysis. The mechanism by which MPA suppresses PGF₂α and permits luteal regression remains to be determined. Three experiments were conducted to determine whether MPA reduces PGF₂α in uteroovarian blood, …
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Biochemistry of ovarian cells in vitro
… prostaglandins, including prostaglandin F₂α (PGF₂α) and PGE₂, on progesterone production by these cells was investigated. PGF₂α„ displayed luteolytic characteristics in this in vitro system by inhibiting both basal and gonadotrophin stimulated progesterone production. In contrast, PGE₂ …
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Relationships among progesterone, estradiol-17β, 13, 14-dihydro-15-keto-prostaglandin F₂α and prostaglandin F₂α in intact ewes around the time of luteolysis
… uterine secretion of prostaglandin F₂α (PGF₂α) are not known. This study (Experiments 1, 2 and 3) was conducted to evaluate the relationships of progesterone and estrogen to changes in 13,14-dihydro-15-keto-prostaglandin F₂α (PGFM) and PGF₂α in ewes. Experiment 1 was designed to determine …
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Fast multipole acceleration of periodic Green's function using spherical harmonics and Ewald summation
… is the use of periodic Green's function (PGF) over free-space Green's function (FGF). When expressed as a spatial sum, PGF converges slowly making this representation unsuitable for numerical implementation. An alternative representation known as Ewald summation can be used to evaluate PGF …
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DEVELOPMENT OF A CULTURE SYSTEM FOR BOVINE LUTEAL CELLS: EXAMINATION OF LUTEOTROPIC AND LUTEOLYTIC MECHANISMS
… metabolism.</p><p>The long-term effects of PGF(,2(alpha)) on luteal function were examined using this cell culture system. PGF(,2(alpha)) has either no effect on basal P(,4) production, or is slightly stimulatory. During the first 24 hours of culture, PGF(,2(alpha)) has no effect on LH-, …
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The FP prostanoid receptor: Isoforms and functional studies
Prostaglandin F₂(α) (PGF₂(α)) is a locally acting hormone derived from arachidonic acid that is involved in a diverse range of physiological functions including regulation of the corpus luteum and regulation of intraocular pressure. The goal of this research has been to characterize the signaling …
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Synchronization of estrus, conception rate, and embryonic mortality in beef cattle following treatment with progesterone-releasing intravaginal devices or melengestrol acetate in conjunction with PGF₂α
… receive either melengestrol acetate for 7 d (MGA-PGF; .5 mg/hd/d, n=136) or progesterone releasing intravaginal device for 7 d (PRID-PGF; n=139) or to serve as untreated controls (n=116). All animals in MGA and PRID treated groups coincidentally received 25 mg prostaglandin F₂α (PGF) on the final …
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Fertility after timed artific[i]al insemination in response to a Controlled Internal Drug Release (CIDR) insert in lactating dairy cows
… parturition, where they received 2 injections of PGF[subscript]2[alpha], 14 d apart (Presynch) beginning between 30 and 36 DIM. Cows (n = 155) detected in estrus after the second PGF[subscript]2[alpha] injection of Presynch were inseminated (early AI). Remaining cows were assigned randomly to be …
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Inflammation, Phagocytosis and Effect of Flunixin Meglumine During Endotoxin-Induced Mastitis (Therapy, Prostaglandins)
… B(,2) (TXB(,2)) and prostaglandin F(,2(alpha)) (PGF(,2(alpha))); (2) the pharmacokinetics of flunixin meglumine in lactating cattle; (3) the clinical efficacy of the flunixin meglumine and its effect on milk and plasma TXB(,2) and PGF(,2(alpha)); and (4) changes of whey immunoglobulins and …
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Induction of the oxytocin receptor and its role in luteolysis in sheep
… secretion of prostaglandin F$\sb{2\alpha}$ (PGF$\sb{2\alpha}$) during spontaneous luteolysis. Continuous treatment with progesterone for 9 or 12 days reduced the density of oxytocin receptors in endometrium and myometrium when compared to the vehicle-treated groups. In the endometrium, …
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A measurement of the contribution of the gluon to the spin of the nucleon
… by seeking evidence of photon-gluon fusion (PGF) deep inelastic scattering events in the form of elementary particles resulting from the decay of charmed particles, which were known to be unique indicators of PGF. Best results indicate ΔG/G = 0.131± 0.164 (stat.) ± 0.131(syst.) at xg = 0.35 …
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Increasing estrus expression in lactating dairy cows
… estrus (estrus was defined: follicle ≥ 10 mm at PGF[subscript 2α] and progesterone ≤ 0.5 ng/mL 72 h later), respectively. In experiment 2, cows (n = 203) were equipped with an AMS and a friction-activated, rump-mounted patch (Estrotect patch; ET) and assigned to receive 1 mg ECP, 2 mg TP, or …
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The Effect of Dietary Alpha - Linolenic Acid on Apparent Risk Factors of Cardiovascular Disease
… 6-keto-prostaglandin F<sub>1α</sub> (6-keto- PGF<sub>1α</sub> ), thromboxane B<sub>2</sub> (TXB<sub>2</sub>), total cholesterol, triglyceride, and total phospholipid fatty acid composition were analyzed at 0, 2 and 4 weeks.</p> <p>Systolic blood pressure increased significantly between weeks 0 …
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells
… effect of Butaprost (EP2 receptor ligand) and PGF (FP receptor ligand) co-administration on inositol phosphate (IP3) and adenosine 3-,5-cyclic monophosphate (cAMP) release was assessed to study a possible heterologous-interaction or cross-talk between the EP2 and FP receptors. The study showed …
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
… polar compound, 6-keto-prostaglandin F₁⍺ (6-keto-PGF₁⍺), prostaglandin F₂⍺ (PGF₂⍺), prostaglandin E₂ (PGE₂), 13,14-dihydro-15-keto prostaglandin F₂⍺ (PGFM), prostaglandin B₂ (PGB₂) and 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). Experiment 2 was to determine whether prostaglandins have a role …
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