Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 120 for “"PGE2"”.
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BV-2 미세아교세포에서 PGE2 에 의한 LPS 유도 IFN-β생성 조절
… 일련의 보고에서 대표적인 proinflammatory mediator 로 잘 알려진 PGE2 가 IFN-β 의 생성을 억제하는 작용이 있는 것으로 보고된 바가 있지만 그 작용 기전에 대해서는 아직 정확히 밝혀진 바가 없다. 본 연구는 PGE2 에 의한 LPS 유도 IFN-β생성 조절기전을 규명하기 위한 연구의 일환으로 TLRs신호전달 과정 중 PGE2 의 표적인자를 확인 하고자 하였다. BV-2 에서 PGE2 는 LPS 또는 poly(I:C) 로 유도된 IFN-β 의 생성을 억제하는 작용을 보였다. IFN-β 의 발현은 …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
<p>Elevated follicular prostaglandin E2 (PGE2) levels are necessary for follicle rupture during ovulation. As the degradation of the follicle wall requires proteolysis, it was hypothesized that regulation of proteolysis by gonadotropins is PGE2 mediated.</p> <p>There are four PGE2 receptors: EP1, …
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Identification of potassium channel subtypes mediating the PGE2-induced sensitization of sensory neurons and regulation of potassium channel gene expression by chronic inflammation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
Prostaglandin E1 (PGE1) and E2 (PGE2) are ligands for the prostaglandin E2 receptor (EP) family, which consists of four subtype receptors, designated as EP1, EP2, EP3 and EP4. Interestingly, PGE2 mediates inflammation whereas PGE1 acts as an anti-inflammatory factor. However, the molecular basis of …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
Prostaglandin E2 (PGE2) is known to be the principal pro-inflammatory prostanoid and play an important role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… (COX-2) and COX-2 generated prostaglandin E2 (PGE2) during pancreatic fibrosis. Pancreatic stellate cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given this background, the primary objective is to delineate the role …
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Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
Prostaglandin E2 (PGE2) is a lipid signaling molecule involved in early healthy brain development. Exposure to environmental risk factors such as air pollutants, infections, and drugs such as acetaminophen during early pregnancy have shown to impact PGE2 levels and have all been linked to Autism …
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Effect of a single intra-articular injection of bupivacaine on synovial fluid prostaglandin E2 concentrations in normal canine stifles
… but may involve inflammation. Prostaglandin E2 (PGE2) is an inflammatory mediator and a marker of joint inflammation. The aim of this study was to compare synovial fluid PGE2 concentrations after a single intra-articular injection of bupivacaine with a saline control in normal canine stifles. We …
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Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
… Als Antwort auf dieses Entzündungsgeschehen wird PGE2 unter anderem von Kupffer Zellen der Leber freigesetzt und kann seine Wirkung über vier PGE2-Rezeptorsubtypen (EP1-EP4) vermitteln. In vorangegangenen Arbeiten konnte gezeigt werden, dass PGE2 in Rattenhepatozyten über den EP3 R ERK1/2-abhängig …
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The Effect of impaired Cyclooxygenase 2 activity on gene regulation in the developing mouse brain and the role of PGE2 in oxidative stress production in Differentiated Neuronal Cells
Prostaglandin E2 (PGE2) is a signaling molecule derived from the lipid membrane through the enzyme cyclooxygenase2 (COX-2). These studies aim to investigate how changes in COX-PGE2 signalling can influence mouse gene expression and alter oxidative stress in neuronal cells. In study 1 we use …
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Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
… be responsible for approximately 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory cytokines. To this end, we utilized RNAi technology, extensively …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… it was postulated that prostaglandin E2 (PGE2), a hormone derived from a main component of maize, continuously triggers activation of proliferation and inflammation pathways. This work aimed at assessing the role of p38, a mitogen-activated protein kinase (MAPK), in the potential of PGE2 …
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Charakterisierung von Prostanoidrezeptoren an Podozyten der Maus
… ([Ca2+]i) untersucht werden. Prostaglandin E2 (PGE2) führte zu einer konzentrationsabhängigen Depolarisation und einem Anstieg der Ganzzellleitfähigkeit in differenzierten Podozyten. Die PGE2 induzierte Depolarisation wurde durch eine erniedrigte Cl- Konzentration in der extrazellulären …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… – leukotriene D4 (LTD4) or prostaglandin E2 (PGE2) – on CIC properties and changes occurring in the tumor environment that could possibly support CIC-induced tumor growth. To this end, we identified the CICs on the basis of ALDH expression and evaluated their in vitro characteristics like …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
In the human uterus prostaglandins (PG) PGE2, PGD2, PGI2, PGF2¿ and Thromboxane A2 (TXA2), also termed prostanoids, are synthesised and deactivated to 15-keto PGE2, J2 metabolites, 6-keto-PGF1¿, 15-keto PGF2¿ and TXB2 respectively. However, not all metabolites have been analysed simultaneously …
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Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line.
… is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to …
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Geburtseinleitung mit 2 mg Prostaglandin-E 2-Vaginalgel bei unreifem Zervixbefund (Bishop-Score 5)
… unreifem Zervixbefund die Applikation von 2 mg PGE2-Vaginalgel der Applikation von 1 mg PGE2-Vaginalgel und 0,5 mg PGE2-Intrazervikalgel überlegen erscheint wurde in dieser Studie überprüft, ob die Geburtseinleitung nach 12 Stunden mit 2 mg PGE2-Gel intravaginal bei unreifer Zervix (Bishop-Score …
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