Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"PGC-1α"”.
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
… coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum of patients with Huntington’s Disease (HD). HD is an autosomal dominant neurological disorder caused by a polyglutamine repeat in the huntingtin protein …
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AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
… muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and subsequent activation of AMPK, a known inducer of PGC-1[alpha] activity and …
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Mechanistic Control of The Coldinduced Augmentation of The Transcriptional Co-Activator PGC-1α
… Despite these recent advances showing PGC-1α, the ‘master regulator’ of mitochondrial biogenesis, being augmented in its post-exercise response by cold water immersion, the precise controlling mechanisms remain to be determined. However, it has been suggested that local cooling effects …
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Using gravity to help us understand the AMPK-PGC-1α axis in skeletal muscle from healthy young males
… gamma coactivator 1-alpha (PGC-1α). Generally, the harder someone exercises (i.e. higher exercise intensities), the more PGC-1α increases. There are also several proteins that ‘turn on’ or activate PGC-1α, and these too increase as exercise intensity goes up. This means …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function …
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… damage. The transcriptional co-activators, PGC-1α and PGC-1β, are important regulators of mitochondrial biogenesis and anti-oxidant capacity. Our group has previously shown that the PGC-1α protein promotes RPE oxidative metabolism and that overexpression of the PGC-1α gene protects cells …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… activated receptor gamma coactivator-1 (PGC-1α) and other transcription factors that act as accessory factors in T3 actions. </p> <p>Thyroid hormone receptors (TRα or TRβ) are part of the nuclear receptor family and have been implicated in the induction of many genes by T3. The nuclear …
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Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
… activated receptor gamma coactivator 1 alpha (PGC-1α), a known regulator of mitochondrial biogenesis. Following the initiation of a high fat diet, we observed significant genotypic (DNA methylation) and phenotypic (mitochondrial copy number) alterations in C57/BL6 rodent models. These changes …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
… receptor gamma co-activator 1-alpha (PGC-1α) and fibronectin type III domaincontaining protein 5 (FNDC5) genes in muscle, circulating Irisin and uncoupling protein one (UCP1) of WAT in humans (study 1); b) to examine the relationship between UCP1 mRNA and protein expression as well as …
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Caracterización de MYBBP como un nuevo gen supresor de tumores
… encontrado que c-MYB activa la transcripción de PGC-1α. Así mismo, la reducción de MYBBP1A activa a PGC-1α directa e indirectamente. De forma directa, la reducción de MYBBP1A permite la actividad de PGC-1α y de forma indirecta aumenta los niveles de PGC-1α a través de la activación de c-MYB. …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… factors (NRF-1 and NRF-2) and their co-regulator PGC-1α---leading to expression of mitochondrial transcription factor A (Tfam), which regulates mitochondrial transcription and replication. Hyperoxia also induced activation of NRF-1 and NRF-2 in EC-SOD KO mice after 6 hours but down-regulated Tfam …
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EFFECT OF POST-EXERCISE COLD WATER IMMERSION ON MOLECULAR RESPONSES TO HIGH-INTENSITY INTERMITTENT EXERCISE
… compared to baseline (P < 0.01). Muscle PGC-1α (3 h, 1.3 ± 0.2-fold; 6 h, 1.4 ± 0.3-fold) and VEGF165 (3 h, 1.9 ± 1.4-fold; 6 h, 2.2 ± 1.0-fold) mRNA expression were significantly increased at 3 h (PGC-1α, P < 0.001; VEGF165, P = 0.03) and 6 h (PGC-1α, P < 0.001; VEGF165, P = 0.009) …
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Muscle adaptations to post-exercise cooling
… expression of the transcriptional coactivator PGC-1α, which is implicated in the regulation of non=shivering thermogenesis. As such, studies 3 and 4 investigated the acute and chronic influence of post-exercise cooling on muscle aerobic adaptations to exercise and exercise training, …
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Modulation of exercise-induced gene expression in human skeletal muscle by exercise intensity, training status and short-term endurance training
… with a larger increase in mRNA abundance of PGC-1α and FOXO1A during recovery. A single bout exercise induced an increase in PGC-1α. FOXO1A, and PDK4 mRNA abundance in both untrained and trained muscle. This may form part of a transcriptional response that contributes to exercise-induced …
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The Effect of Leucine Supplementation on Biomarkers of Mitochondrial Biogenesis and Protein Synthesis in Soleus Muscle of Rats Fed a High-Fat Diet
… and mitochondrial biogenesis regulatory factors PGC-1α and COX-IV. METHODS: Male, Sprague-Dawley rats (n = 30 / dietary treatment) were fed either a control diet (C), control + leucine (CL), high-fat (HF), or high-fat + leucine (HFL) for 42 days. At the conclusion of 42 days, the soleus was …
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Enhanced methylglyoxal formation in cystathionine γ-lyase knockout mice
… proliferator-activated receptor-γ coactivator (PGC)-1α, and its down-stream targets, FBPase-1 and -2, phosphoenolpyruvate carboxykinase (PEPCK), and estrogen-related receptor (ERR)α mRNA expression levels in renal extracts from 6-22 week-old CSE⁻/⁻ mice. Likewise, FBPase-1 and -2 mRNA levels …
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Regulation of LKB1-STRAD-MO25 Complex Expression and Activation of AMPK in Skeletal Muscle by Thyroid Hormone
… expression of LKB1, MO25, and STRAD, as well as PGC-1α, increased in the soleus of thyroid hormone treated rats vs. the controls. MO25 mRNA increased with thyroid hormone treatment, and STRAD mRNA increased with PTU treatment. Phospho-AMPK and phospho-ACC increased in response to electrical …
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