Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"PGC-1α"”.
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
… coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum of patients with Huntington’s Disease (HD). HD is an autosomal dominant neurological disorder caused by a polyglutamine repeat in the huntingtin protein …
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Mechanistic Control of The Coldinduced Augmentation of The Transcriptional Co-Activator PGC-1α
… Despite these recent advances showing PGC-1α, the ‘master regulator’ of mitochondrial biogenesis, being augmented in its post-exercise response by cold water immersion, the precise controlling mechanisms remain to be determined. However, it has been suggested that local cooling effects …
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AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
… muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and subsequent activation of AMPK, a known inducer of PGC-1[alpha] activity and …
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Using gravity to help us understand the AMPK-PGC-1α axis in skeletal muscle from healthy young males
… gamma coactivator 1-alpha (PGC-1α). Generally, the harder someone exercises (i.e. higher exercise intensities), the more PGC-1α increases. There are also several proteins that ‘turn on’ or activate PGC-1α, and these too increase as exercise intensity goes up. This means …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function …
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… damage. The transcriptional co-activators, PGC-1α and PGC-1β, are important regulators of mitochondrial biogenesis and anti-oxidant capacity. Our group has previously shown that the PGC-1α protein promotes RPE oxidative metabolism and that overexpression of the PGC-1α gene protects cells …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… activated receptor gamma coactivator-1 (PGC-1α) and other transcription factors that act as accessory factors in T3 actions. </p> <p>Thyroid hormone receptors (TRα or TRβ) are part of the nuclear receptor family and have been implicated in the induction of many genes by T3. The nuclear …
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Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
… activated receptor gamma coactivator 1 alpha (PGC-1α), a known regulator of mitochondrial biogenesis. Following the initiation of a high fat diet, we observed significant genotypic (DNA methylation) and phenotypic (mitochondrial copy number) alterations in C57/BL6 rodent models. These changes …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
… receptor gamma co-activator 1-alpha (PGC-1α) and fibronectin type III domaincontaining protein 5 (FNDC5) genes in muscle, circulating Irisin and uncoupling protein one (UCP1) of WAT in humans (study 1); b) to examine the relationship between UCP1 mRNA and protein expression as well as …
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Caracterización de MYBBP como un nuevo gen supresor de tumores
… encontrado que c-MYB activa la transcripción de PGC-1α. Así mismo, la reducción de MYBBP1A activa a PGC-1α directa e indirectamente. De forma directa, la reducción de MYBBP1A permite la actividad de PGC-1α y de forma indirecta aumenta los niveles de PGC-1α a través de la activación de c-MYB. …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… factors (NRF-1 and NRF-2) and their co-regulator PGC-1α---leading to expression of mitochondrial transcription factor A (Tfam), which regulates mitochondrial transcription and replication. Hyperoxia also induced activation of NRF-1 and NRF-2 in EC-SOD KO mice after 6 hours but down-regulated Tfam …
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EFFECT OF POST-EXERCISE COLD WATER IMMERSION ON MOLECULAR RESPONSES TO HIGH-INTENSITY INTERMITTENT EXERCISE
… compared to baseline (P < 0.01). Muscle PGC-1α (3 h, 1.3 ± 0.2-fold; 6 h, 1.4 ± 0.3-fold) and VEGF165 (3 h, 1.9 ± 1.4-fold; 6 h, 2.2 ± 1.0-fold) mRNA expression were significantly increased at 3 h (PGC-1α, P < 0.001; VEGF165, P = 0.03) and 6 h (PGC-1α, P < 0.001; VEGF165, P = 0.009) …
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Muscle adaptations to post-exercise cooling
… expression of the transcriptional coactivator PGC-1α, which is implicated in the regulation of non=shivering thermogenesis. As such, studies 3 and 4 investigated the acute and chronic influence of post-exercise cooling on muscle aerobic adaptations to exercise and exercise training, …
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Modulation of exercise-induced gene expression in human skeletal muscle by exercise intensity, training status and short-term endurance training
… with a larger increase in mRNA abundance of PGC-1α and FOXO1A during recovery. A single bout exercise induced an increase in PGC-1α. FOXO1A, and PDK4 mRNA abundance in both untrained and trained muscle. This may form part of a transcriptional response that contributes to exercise-induced …
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The Effect of Leucine Supplementation on Biomarkers of Mitochondrial Biogenesis and Protein Synthesis in Soleus Muscle of Rats Fed a High-Fat Diet
… and mitochondrial biogenesis regulatory factors PGC-1α and COX-IV. METHODS: Male, Sprague-Dawley rats (n = 30 / dietary treatment) were fed either a control diet (C), control + leucine (CL), high-fat (HF), or high-fat + leucine (HFL) for 42 days. At the conclusion of 42 days, the soleus was …
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Enhanced methylglyoxal formation in cystathionine γ-lyase knockout mice
… proliferator-activated receptor-γ coactivator (PGC)-1α, and its down-stream targets, FBPase-1 and -2, phosphoenolpyruvate carboxykinase (PEPCK), and estrogen-related receptor (ERR)α mRNA expression levels in renal extracts from 6-22 week-old CSE⁻/⁻ mice. Likewise, FBPase-1 and -2 mRNA levels …
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Regulation of LKB1-STRAD-MO25 Complex Expression and Activation of AMPK in Skeletal Muscle by Thyroid Hormone
… expression of LKB1, MO25, and STRAD, as well as PGC-1α, increased in the soleus of thyroid hormone treated rats vs. the controls. MO25 mRNA increased with thyroid hormone treatment, and STRAD mRNA increased with PTU treatment. Phospho-AMPK and phospho-ACC increased in response to electrical …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… of TFAM was accompanied with increased PGC-1α and NRF1 expressions through the activations of LKB1 and AMPK due to increased activity of PKCζ in old cells. These signaling pathways are important in regulating the mitochondrial encoding OXPHOS complex subunit genes and respiration as well …
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