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Showing 1 to 2 of 2 for “"PFTase"”.
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Studies and applications of protein prenylation using isoprenoid analogues and site-directed mutagenesis
… therapeutics. Protein farnesyltransferase (PFTase) is a promising tool in the field of site-specific protein modification due to its substrate promiscuity, small recognition domain and mild reaction conditions. PFTase is an enzyme that attaches a farnesyl moiety, from farnesyl diphosphate …
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Total Syntheses of (+)-Geldanamycin, (-)-Ragaglitazar, and (+)-Kurasoin A and Phase-Transfer-Catalyzed Asymmetric Alkylation
… a relatively potent protein farnesyltransferase (PFTase) inhibitor with an IC50 value of 59.0 micromolar. PTC glycolate alkylation was optimized to provide 4-benzyloxy glycolate intermediates in excellent overall yield and with 96% ee after recrystallization. Ragaglitazar was then synthesized …