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Showing 1 to 4 of 4 for “"PFKFB3"”.
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Insights into the role of PFKFB3 in cancer
PFKFB3, an isoform of PFK-2, which is highly expressed in cancer cells, has been suggested to be associated with enhanced aerobic glycolysis in cancer by elevating the intracellular levels of key glycolytic activator, Fru-2,6-P2. This work describes the importance of PFKFB3 function in metabolic …
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Regulation of Akt ignal transduction by glucose metabolism
… sphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (PFKFB3). Intriguingly, the expression of PFKFB3 in adipocytes is extremely high compared to most other tissues. I observed an insulin-dependent induction of aerobic glycolysis in adipocytes through lactate production and hypothesised that this …
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Insights into the Development of Chemotherapeutics Targeting PFKFB Enzymes
… and heart disease. The inducible isoform, PFKFB3, is known to be associated with the upregulation of glycolysis in many cancers. The first study within this work investigates the potential for using tier-based approaches of virtual screening to target small molecule kinases, with PFKFB3 …