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Showing 1 to 3 of 3 for “"PEX5"”.
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The circadian role of Pex5 in glial cells and implications of Pex5 in sleep behavior and brain lipidome
… required the circadian clock and Peroxin 5 (Pex5; peroxisomal biogenesis factor 5 homolog), with import persistently elevated in clock mutants. Notably, reducing Pex5 in cortex glia, but not neurons, caused hyperactivity and reduced total sleep. Moreover, brain lipid metabolism was …
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Aging Lowers Pex5 Levels In Cortical Neurons In Male and Female Mouse Brains
… HD mouse model, neuronal levels of PEX5, (a peroxisomal protein involved in clearance and homeostasis of peroxisomes) and ACAA1 (a peroxisomal marker), were lower than in control groups, suggesting that before HD symptoms begin, mHtt expression may reduce peroxisomal number in …
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Konditionale Inaktivierung von Peroxisomen im Nervensystem der Maus : ein transgenes Modell einer humanen Leukodystrophie
… des peroxisomalen Biogenesefaktor Peroxin 5- (PEX5) Gens mit LoxP-Sequenzen flankiert worden waren. Anhand von Zellkulturanalysen konditionaler PEX5 null-mutanter Mäuse (CNP-Cre*floxPEX5) konnte die Expression von Cre und eine damit verbundene Defizienz von PEX5 in Oligodendrozyten nachgewiesen …