Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PET tracers"”.
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Evaluation of new PET tracers for receptor tumour imaging
PET imaging can be used to non-invasively characterise biological processes at the molecular and cellular levels. The oestrogen receptor (ER) and progesterone receptor (PR) are important biomarkers in the diagnosis, prognosis and follow-up of the therapeutic response of breast cancer. Determination …
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Development of 89Zirconium-PET Tracers for Immune Cell Imaging
… cell therapies. Positron Emission Tomography (PET) is a powerful non-invasive imaging technique that can be utilised for spatial and longitudinal tracking of different cell types. The long half-life PET isotope zirconium-89 (t1/2 = 78.4 h) has become increasingly available and [89Zr]Zr-Oxine …
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Synthesis, Radiolabeling and Evaluation of a suite of Tracers with <sup>44</sup>Sc for Detecting Extracellular DNA
… quantitation has yet to be achieved. A class of PET tracers are described here that consists of a DNA dye as the backbone that is labeled with an emerging positron emitting isotope of research and clinical interest, <sup>44</sup>Sc. We describe the synthesis and radiolabeling of several NET …
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Design and synthesis of novel compounds as fatty acids binding protein inhibitors and as gallium-68 chelators for positron emission tomography
… gallium, for their potential applicability as PET tracers. The two compounds were then evaluated as effective 68-gallium chelating compounds and the result showed their capability in the binding of the 68Ga.
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
… such as positron emission tomography (PET), may be useful for understanding the complex role of the endocannabinoid system in animals and humans. Our major focus was to prepare novel fluorinated analogs of tetrahydrocannabinol (THC)-type, cannabidiol (CBD)-type, cannabicyclol …
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Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents
… sensitive in vivo positron emission tomography: PET) tracers at low administering doses. The "pre-grafting" strategy was further extended to accomplish SCKs with variable biodistributions. PAA-b-PS amphiphilic block copolymers were modified with varying numbers of poly(ethylene oxide): PEO) …
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Drug discovery for misfolding diseases using structure-based iterative learning
Computational methods such as machine learning hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is pressing for neurodegenerative diseases, where the development of disease-modifying drugs has been particularly challenging. The high …