Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"PET Imaging"”.
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Compressive Sensing in Positron Emission Tomography (PET) Imaging
Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in cancer). PET scanners use multiple rings of gamma ray detectors that surround the patient. These scanners are …
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Identifying Response to Therapy in Longitudinal PET Imaging Studies
18F-FDG PET can predict response using both qualitative and quantitative measures. PET Therapy Response Assessor (PETTRA) software was developed to allow users to view and analyse pre- and post- therapy images and compute quantitative measures for predicting response to therapy. Additionally, …
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Radiolabeled Bombesin Analogs to Improve Prostate Cancer Diagnosis by PET Imaging
Le récepteur du peptide de libération de la gastrine (GRPR) est un récepteur couplé aux protéines G. Ce récepteur est fortement exprimé dans le cancer de la prostate, il est ainsi un biomarqueur potentiel pour ce cancer. La bombésine est un peptide de 14 acides aminés qui se lie avec une forte …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
Imaging molecular techniques including PET, CT, MRI allow to detect and to monitor normal and pathological conditions non-invasively in clinic. The recent development of dedicated small animal instruments together to the availability of appropriate animal models of disease has allowed the use of …
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Evaluation of room-temperature semiconductor detectors for ultrahigh resolution pet imaging
… resolution positron emission tomography (PET) imaging is presented. The approach is based on the use of a CdTe semiconductor detector. The detector is a 2mm thick cadmium telluride (CdTe) detector with a pixel pitch of 350μm x 350μm; it is bump bonded to an energy-resolved photo-counting …
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The Development of Peptide Analogues as Potential Fluorescent and PET Imaging Probes.
Molecular imaging is a non-invasive way to diagnose disease. Molecular imaging probes consist of a targeting entity that has a high affinity for a biological target and a signaling source for external detection. Multimodality imaging combines the advantages of different imaging modalities, at the …
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… and tissues. One such methodology is molecular imaging with positron emission tomography (PET), which allows for non-invasive visualization and quantification of spatial and temporal dynamics of expression-activity of various receptors and enzymes in different organs and tissues in norm and …
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Statistical analysis of 11CO2 contamination correction in 11C-acetate PET imaging studies
Positron Emission Tomography (PET) is a noninvasive imaging modality widely used in cancer management and medical research. It supports diagnosis, prognosis, treatment monitoring, and clinical decisions by tracking radiotracers labeled with positron-emitting isotopes. Tracer choice depends on the …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… 1) bioconjugation strategies, 2) immunoPET imaging, and 3) radioimmunotherapy. This dissertation will attempt to comprehensively cover each of these categories through a series of studies, protocols, and reviews. For the bioconjugation strategies, we will describe the development of a …
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Experimental evaluation of Compton-enhanced PET imaging with 3-D CZT imaging sensors
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… class of radiopharmaceuticals for diagnostic imaging and cancer therapy. Following radionuclide labeling, the specific receptor-binding properties of the ligand can be exploited to guide the radioactivity to tissues expressing a particular receptor. This dissertation reports on the development …
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Novel Interactions of the Hormone Leptin Revealed by PET Imaging in Rodents and Rhesus Macaques
… using positron emission tomography (PET). Two complementary techniques were developed to label leptin using the positron emitting isotopes 68Ga and 18F. 68Ga labeling was accomplished by lysine-directed conjugation with the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic …
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PET-imaging in depression and antidepressant therapies : focus on the serotonin system and the cerebral glucose metabolism
… Hereby, several studies were performed using the PET radiotracer [11C]DASB, which specifically targets the serotonin transporter. To allow qualitative and safe research with this radiotracer, the first research topic focussed on the optimization of the radiotracer’s purification procedure and its …
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Hybrid pixel-waveform semiconductor detectors: novel detector readout for semiconductor pet imaging of small animal neurodegenerative models
… the contextual importance of developing nuclear imaging instrumentation for application specific purposes by focused discussion on preclinical pathological dementia imaging. To this end, this work explores the potential use of small pixel hybrid pixel-waveform (HPWF) CdTe detectors for PET by …
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Invasive Physiologic Assessment of Myocardial Viability After Primary Angioplasty in Acute Myocardial Infarction: Comparison With FDG-PET Imaging
… mean transit time. 18F-fluorodeoxyglucose (FDG) PET was performed after primary PCI in 7 days to evaluate myocardial viability by regional percentage uptake of FDG in infarct-related segments. RESULTS: Among Doppler-derived parameters, regional FDG-uptake was associated with baseline average peak …
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THE RELATIONSHIP BETWEEN BRAIN AND SYSTEMIC METABOLISM IN ALZHEIMER’S DISEASE AS ASSESSED BY DUAL-TRACER ACETOACETATE/FLUORODEOXYGLUCOSE PET IMAGING
… usage may relate to various tissue and neuroimaging biomarkers – which may be used to identify early pathology and response to therapeutic intervention.
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