Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"PERK signalling"”.
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Biochemical and Biophysical Studies of the UPR Kinase PERK and its Interactors in Health and Disease
… of endoplasmic reticulum (ER) stress. The PERK-eIF2α branch of the UPR is activated by the accumulation of misfolded proteins in the ER lumen. PERK, upon activation through autophosphorylation, recruits its substrate eIF2α for phosphorylation, initiating a transcriptional and translational …
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Biochemical Studies of the ER Resident Kinase PERK and Implications for Local Translational Control
… R (PKR)-like endoplasmic reticulum kinase (PERK) is able to couple ER stress to translational repression and transcriptional reprogramming through phosphorylation of eIF2α. This is achieved through the recruitment of eIF2α by a unique cytoplasmic loop in PERK’s kinase domain. PERK signalling …
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Nutraceutical modulation of lipotoxicity and the development of a tool to monitor palmitate induced sub-cellular dysfunction.
… long chain ceramide concentrations, through PERK signalling. This provides a possible combining mechanism for curcumins anti-inflammatory and cytotoxicity phenotypes. Lastly (Chapter 6), a protocol for monitoring the sub-cellular relocalisation of proteins and lipids is developed using the …
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Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
… is often an activating mutation in key cell signalling hub KRAS. Despite extensive research into PDAC and KRAS, the impact of both genetic and non-genetic variability during the earliest steps of carcinogenesis are scantly described. We hypothesise that both forms of heterogeneity might alter …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… and quantitative differences in T cell signalling may underlie the differential functional outcomes of priming and tolerance. However, the majority of these studies have relied upon biochemical assessment of signalling in T cell lines or clones, at the population level following …