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Showing 1 to 20 of 26 for “"PENTOBARBITAL"”.
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Intracellular distribution of pentobarbital sodium in rat brain
… distribution of a particular barbiturate, pentobarbital sodium, within rat brain cells."--Introduction
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Supraspinal actions of pentobarbital on transmission through the spinothalamic tract
… 2001) have reported that microinjections of pentobarbital (PB) into a discrete brainstem focal area of conscious rats induced a classical, reversible general anesthesia-like behavioral state. The authors concluded that this area, termed the mesopontine tegmental anesthesia area (MPTA), may be …
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Effects of some analeptic drugs against deep pentobarbital anesthesia in dogs
Thesis (M.S.)--Michigan State University. Dept. of Pharmacology, 1965
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Mechanism of Action of Pentobarbital Induced Attenuation of Vascular Smooth Muscle Contraction
<p>Pentobarbital (PB) vasodilates dog mesenteric and cerebral arteries precontracted with KC1, PGF<sub>2α</sub>, caffeine or norepinephrine. It is postulated that PB causes this dilation by reducing Ca<sup>2+</sup> influx as a non-specific Ca<sup>2+</sup> channel blocker, or decreasing …
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Pentobarbital Sleep Time in Mouse Lines Selected for Resistance and Susceptibility to Fescue Toxicosis
… (as assessed by sleep time following sodium pentobarbital anesthesia), 2. to determine whether sleep time differences between lines were modulated by fescue toxins or enzyme inducers in the diet, and 3. to determine whether sleep time differences among individual mice were correlated with the …
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The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on <i>In Vitro</i> Mouse Embryonic Development
… range for mice (propofol 50-200mg/kg, sodium pentobarbital 50mg/kg, and ketamine hydrochloride 50-100mg/kg) for 72h to determine the effects of each anesthetic on subsequent cleavage and development during prolonged exposure. The anesthetic dosage ranges were as follows: propofol 0-25.0μg/mL, …
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Indagine etnofarmacologica su Casimiroa edulis Llave et Lex
… induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of immobility (like-antidepressant action); it reduced …
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A Comparison of ECS and Drug Induced State-Dependent Learning
… relative to three different dosages of sodium pentobarbital preselected to produce no, moderate, and complete dissociation.
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Discriminative Stimulus Effects of Gabapentin
… for itself at 30.0, 60.0, and 120.0 mg/kg doses. Pentobarbital produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The …
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Basal Release of Endothelium-derived Nitric Oxide in Thyropathologic Rat Aorta
… sacrificed by either cervical dislocation or pentobarbital injection followed by thoracic opening to test for sacrifice differences. Three aortic rings from each rat were mounted in environmentally-controlled tissue baths and contracted with different concentrations (10 nM, 100 nM, and 1 mM) …
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Functional relationship between forebrain cholinergic projections and somatostatin neurons in the rat
… choline uptake was tested by injection of pentobarbital, a drug known to decrease high affinity choline uptake. We detected a decrease in high affinity choline uptake after pentobarbital administration, indicating that if cysteamine were decreasing high affinity choline uptake, the assay …
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The reduction of tolerance to the anticonvulsant effects of antiepileptic drugs
… of dose on the development of tolerance to pentobarbital. During the tolerance-development phase, amygdala-kindledrats received one of the following before each bidaily (one every 48 hr) stimulation: either the same high dose (50.0 mg/kg), the same low dose (10.0 mg/kg), a series of doses …
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Effects of a polychlorinated biphenyl in mice caged at different densities and fed at different nutritional levels
… only) and hepatic microsomal enzyme activity. Pentobarbital- induced sleeping times were used as an index of enzyme activity. A competitive protein binding assay was used for determining plasma corticoid levels. PCBs (200 and 1000 ppm) in the diet of male white mice for 2 weeks significantly …
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The Effect of Glycogen Depletion on Sarcoplasmic Reticulum Function
… end of the hour the rats were anesthetized with pentobarbital sodium (60 mg/kg:ip) for tissue harvesting. Upon reaching a surgical plane of anesthesia one gastrocnemious muscle was extracted for the muscle glycogen assay and the other removed for SR vesicle preparation. Rats were then euthanized …
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The Effect of 48 hr Glucose Administration on the Hepatic P-450 System
… prolonged anesthesia after the administration of pentobarbital. The spectral binding of hexobarbital and methadone to hepatic microsomal P-450 was found to be significantly reduced following glucose administration. The changes in spectral binding were observed in the absence of any significant …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
… (RyR) channels is unlikely. The barbiturate pentobarbital and the dissociative anaesthetic ketamine used at clinical EC50 concentrations were also shown to inhibit nAChR-induced increases in [Ca2+]i. In conclusion, thiopental and other i.v. anaesthetics may inhibit nAChR-induced currents and …
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Characterization of Sympathetic Ganglion Sensitivity to Substance P in a Genetic and a Non-Genetic Rat Model of Hypertension.
… of the superior cervical ganglion (SCG) in pentobarbital anesthetized rats. Animals were treated with the ganglion blocking agent chlorisondamine (10.5 μmol/kg) and pre- and postganglionic SCG nerves were cut. SP (1.0 to 100 nmol/kg) evoked a greater increase in postganglionic nerve firing …
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Barbiturate treatment in experimental transient focal cerebral ischaemia
… the clinical event. In this experiment pentobarbital therapy would be delayed for 1 hour to provide for the expected delay that would occur from the onset of ischaemia to the institution of treatment. Similarly, ischaemia was to last 4 hours to allow for a minimum time interval necessary …
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… Subsequently, I also investigated effects of pentobarbital on spontaneous and thermal stimulus evoked PAG neuronal firing, as has often been done in previous pain studies. Administration of low doses of pentobarbital significantly decreased PAG spontaneous firing and evoked excitatory and …
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Vascular Effects of PHYSALIA PHYSALIS Venom
… dogs were anesthetized with 35 mg/kg sodium pentobarbital. Arterial pressure was measured from the aortic arch and the cranial femoral artery, a cephalad branch of the femoral artery. The skeletal muscle venous blood flow of the hind leg was functionally isolated. Femoral vein blood flow and …
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