Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"PEITC"”.
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… (OSW-1) and β-Phenylethyl Isothiocyanate (PEITC) in melanoma.</p> <p>OSW-1 inhibited melanoma cell viability at nanomolar concentrations with minimal toxicity to normal melanocytes. Mechanistic studies revealed that OSW-1 suppressed Disialoganglioside 3 Synthase (GD3S) gene expression in …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… (BITC) and phenethyl isothiocyanate (PEITC) on the metabolism and mutagenicity of 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) and benzo[a]pyrene (BaP) by F344 rat and male Syrian golden hamster liver microsomes were investigated. In addition, the alkyl chain-length effects of …
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Impact of Dietary Bioactive Components in Chronic Diseases Using Nutrigenomics, Nutriepigenomics, and Metagenomics Approaches
… vegetablesderived phenethyl isothiocyanate (PEITC) in cancer prevention, using next generation “omics” technologies and molecular nutrition approaches. RS4 flour (30%) enriched differential abundance of 71 bacterial operational taxonomic units in fecal samples obtained from Hutterite …
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
… the dietary agent phenethyl isothiocyanate (PEITC). We found that PEITC reacts with KEAP1 C151 to stabilize NRF2, and that it is able to activate the HSR by activating HSF1 through the inhibition of heat shock protein 90, the main negative regulator of HSF1. We further showed that PEITC …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
… modulating reagent β-phenethyl isothiocyanate (PEITC) has been found to efficiently deplete GSH and induce potent cell killing effects in drug-resistant CML cells. Combination of PEITC with BCL-XL/BCL2 inhibitor ABT737 or suppression of BCL-XL by BCR-ABL inhibitor Gleevec dramatically sensitizes …
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A quantitative analysis of chemotherapy-induced reactive oxidative species using genetically encoded sensors and generators
… chemotherapeutics, phenethyl isocyanate (PEITC) and piperlongumine. We found that depletion of the glutathione antioxidant by these drugs was unimportant to the toxicity mechanism, and the amount of oxidative stress generated by these compounds was not enough to induce significant toxicity …