Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 73 for “"PEGylated"”.
-
Vibrational Spectroscopy of Self-Forming Synthetic PEGylated Lipids and Nanovesicles
… of newly developed self-forming synthetic PEGylated lipids, trademarked as QuSomes. In contrast to conventional phospholipids, these new kind of lipids spontaneously form liposomes or nanovesicles upon hydration, without the supply of external activation energy. The amphiphiles considered …
-
Hydrodynamic behavior and thermal stability of a PEGylated protein: Studies with hen egg lysozyme
… produce mono (PEG1-HEL), di (PEG2-HEL), and triPEGylated (PEG3-HEL) species.</p><p>The hydrodynamic properties of HEL were altered upon PEGylation. A decrease in sedimentation (s) and diffusion (D) coefficients was observed for all three PEG-HEL molecules in comparison to HEL (1.81 s). Despite …
-
PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
… was initiated to evaluate several different PEGylated TP508 derivatives in an attempt to increase TP508 efficacy or decrease the therapeutic dose required for efficacy. We demonstrate that the circulating half-life of TP508 derivatives increase in a size-dependent manner with the length of …
-
Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin
… improved. Today a combination therapy with pegylated interferon a (PEG-IFN) and ribavirin is recommended. The sustained virological response rate six months after stop of treatment (SVR) is about > 55% in treatment naive patients. Because the treatment with PEG-IFN plus ribavirin is 6 to 12 …
-
Synthesis, characterization and biological studies of carboranyl-porphyrin bioconjugates for treatment of brain tumors
… (In vitro and In vivo) of high boron containing pegylated cobaltabisdicarbollide porphyrin for treatment of brain tumors using BNCT. To improve the selectivity towards brain tumors we attempted conjugate several peptides to this non-toxic pegylated cobaltabiscabollide porphyrin. In vivo studies …
-
Sustained hydrogel-based delivery of RNA interference nanocomplexes for gene knockdown
… (PEG-VS) hydrogels, unmodified fibrin and PEGylated fibrin hydrogel. The nanocomplex release rate in vitro from the various hydrogels showed minimal release from PEGylated hydrogels, burst release from unmodified fibrin and sustained release from PEGylated fibrin. Invivofectamine® 3.0 …
-
Zirconium-based metal-organic frameworks as drug delivery systems
… (mPEG-PO3) followed by lyophilisation. These PEGylated nanoMOFs were able to maintain their hydrodynamic diameter in water and PBS compared to their non-PEGylated counterparts. PEGylated nanoMOFs also reduced cytotoxicity in vitro and were taken up by HeLa cells within 24 hours of incubation. …
-
Design, Fabrication and Performance Evaluation of an Impedimetric Urea Biosensor System
… as the sensor's response. Five formats: [i) unPEGylated urease-containing poly(hydroxyethylmethacrylate) [p(HEMA)] hydrogel, ii) PEGylated urease-containing p(HEMA) hydrogel, iii) via glutaraldehyde crosslinking in the presence of albumin, iv) the direct covalent immobilization of urease to the …
-
13C PEG as an In Vivo Macromolecular Probe for MRI and Biophysical Studies of Detergent-Peptide and Detergent-Detergent Interactions using NMR
… by monitoring the real-time clearance of PEG and pegylated albumin in the hind leg of a mouse. Improvements to the initial imaging methodology are subsequently proposed, which increase the sensitivity and extend the imaging capabilities to abdominal and cranial regions. Ex vivo detection of …
-
Advancing prostate cancer therapy: synthesis and characterization of docetaxel-loaded magnetic iron oxide nanoparticles for controlled drug release.
… the present study was to synthesize DXL-loaded pegylated magnetic Iron oxide nanoparticles (Fe3O4NPs) for controlled drug release in prostate cancer cells. In this study, Fe3O4NPs were synthesized by the co-precipitation, functionalized with folic acid (FA), loaded with DXL and encapsulated with …
-
Zein-based nanoparticles for drug delivery applications
… to zein ratio. In vitro studies revealed that PEGylated zein micelles could deliver a model hydrophobic substance, Nile red, into B16-F10-luc-G5 melanoma cells in a time-dependent manner, with higher cellular uptake observed when using smaller chain length PEG5K and lower PEG density. The …
-
The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates
… polyethylene glycol coated gold nanoparticles (PEGylated Au NPs) through photophysics and transport studies. A detailed investigation of Pc 4’s photophysical behavior in water both with and without Au NPs is presented, elucidating the role of intramolecular photoinduced electron transfer and …
-
Functional DNA Aptamers as Biotherapeutic Molecules
… the in vivo targeting of nanoparticles such as pegylated liposomes to tumour cells was enhanced by introducing tumour marker-specific DNA aptamers on their surface. The CEA-specific aptamer N54 and a 40-base second generation aptamer MUC1-VR1 that recognizes the tumour-associated mucin MUC1 were …
-
A family of multi-functional phosphorescent bioprobes based on the PtPFPP scaffolding moiety
… We also synthesized the di-glucosilated-di-PEGylated derivative, named as PtmPEG21Glc2 (trans), in which 1-thio-β-D-glucose (1Glc) and thio-methyl-polyethylene-glycol (mPEG) moieties were covalently attached to PtPFPP in trans- position. Tetra-substituted derivatives Pt1Glc4, Pt2Glc4, …
-
Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment
… of protein to the surface of liposome and PEGylated liposomes were investigated. Proteins with or without membrane binding domain were conjugated to liposome and PEGylated liposomes through covalent and non-covalent binding for comparison. A modified enzyme-linked immune sorbent assay was …
-
Production and Surface Modification of Protein Microspheres
… targeting of folate labeled polyethylene glycol (PEGylated) liposomes to tumors that express folate receptors. Adaptation of this technology allowed approximately 6000 folate-PEG polymers per microsphere to be covalently linked to the surface of the albumin microspheres. A flow cytometry assay …
-
Turning stealth liposomes into cationic liposomes for anticancer drug delivery
… Previously reported passive tumor targeting by PEGylated liposomes (stealth liposomes) have resulted in their higher tumor accumulation. However their interaction with cancer cells has been minimal due to the steric hindrance of the PEG coating. This dissertation reports two approaches to …
-
Stealth Polymer Conjugates of Biologics
… that is colloquially termed PEGylation. PEGylated drug conjugates have a much longer plasma half-life than the native drug due to their larger size leading to slower renal clearance, reduced opsonization that reduces clearance by the reticuloendothelial system (RES) organs, and improved …
-
The Effect of PEG-Insulin and Insulin Hexamer Assembly on Stability in Solution and Dry Powders. Hexamer Assembly of PEGylated-Insulin and Insulin Studied by Multi-Angle Light Scattering to Rationally Choose the pH and Zinc Content for Analytical Methods and Formulations of Dry Powders.
… and the self assembly properties of insulin and PEGylated insulin in solution. Polyethylene glycol (PEG) chains were covalently attached to insulin in order to evaluate their impact on insulin¿s systemic duration of action after pulmonary dosing. This thesis will focus on the assembly properties …
Page 1 of 4