Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"PECAM"”.
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Moesin in Thrombozyten interagiert mit PECAM-1 : Bedeutung für die Atherosklerose und Restenose
… In this study we investigated whether PECAM-1 (platelet endothelial cell adhesion molecule-1) is a membrane-binding partner for moesin in human platelets. The juxta-membrane cytoplasmic domaine of PECAM-1 contains a cluster of positively charged aminoacid-residues similar to the known …
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Expressionsmuster der Adhäsionsmoleküle P-Selektin, von Willebrand-Faktor und PECAM-1 in der Lunge von Todesfällen durch Verbrennungsschock versus Verblutungsschock
… mit P-Selektin, von-Willebrand-Faktor (vWF) und PECAM-1 untersucht. Die Untersuchungsergebnisse zeigten statistisch signifikante Unterschiede zwischen Verbrennungsschock und Verblutungsschock. <br>Es konnte eine starke Anfärbung für P-Selektin (insbesondere im Gefäßlumen) und vWF (insbesondere am …
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Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI
… of endothelial and mural cell markers (i.e. PECAM-1 and PDGFRβ, respectively) in immunohistochemically-stained brain sections demonstrates that EphA4 silencing does not seem to affect the physical association between, nor total amounts of, endothelial cells and pericytes, between genotypes by …
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Intracellular sphingosine kinase activity as a regulator of endothelial cell inflammatory and angiogenic potential.
… platelet endothelial cell adhesion molecule-l (PECAM-l), which was upregulated and dephosphorylated and critical in SK-induced cell survival. Thus raised intracellular SK activity enables a PECAM-l-dependent activation of the PI-3K1Akt pathway to augment cell survival, thus exposing a hitherto …
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… nrf2 (HO-1), NFĸB (IL-6 mRNA), HIF-1α (VEGF) and PECAM-1 - were examined. HIF-1α, nrf2, HO-1, PECAM-1, VEGF, and NFᴋB levels were detected by immunocytochemical/immunohistochemistry and/or by Western blotting (WB). Total RNA was isolated from HDMEC and cDNA prepared and amplified for each …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
… EMPA+insulin treatment in the tibialis anterior. PECAM mRNA and VEGFa protein expression was also not impacted by EMPA+insulin treatment. EMPA has no obvious impact on the vasculature of SM in type 1 diabetic rodents.
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Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells
… cell-specific marker genes (vWF, VE-cadherin, PECAM-1), tight junction protein genes (ZO-1, OCLD, CLD5) and vasodilatory genes (eNOS, COX-2), while it attenuated the expression of the vasoconstrictive gene ET1. After reduction of HSPG with Hep III, the shear stress-induced expression of vWF, …
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Characterisation of cytokine secretion in malignant gliomas
… platelet and endothelial cell adhesion molecule (PECAM-1), stem cell factor (SCF), prolactin, soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) and urokinase plasminogen activator (uPA). The data also show that tumour tissue revealed increased expression of follistatin and G-CSF …
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Beta 3 integrins : negative regulators of angiogenesis
… and expressed specific antigens including PECAM-1, ICAM-1, ICAM-2, VCAM-1 and VE-cadherin. Using this method, cells from wild-type and beta 3-integrin-deficient animals were purified and used to determine the specificity of a novel potential anti-angiogenic drug. This study shows that …
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Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
… platelet endothelial cell adhesion molecule 1 (PECAM- 1) and vascular endothelial growth factor receptor 2 (VEGFR2). Research conducted by our group has previously shown that exchange protein activated by cAMP (EPAC1) and cyclic nucleotide phosphodiesterase 4D (PDE4D) populate a multi-protein …
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A study of platelets and the endothelium in idiopathic pulmonary fibrosis
… significant difference in the prevalence of the PECAM-1 polymorphisms in IPF and controls.
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The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
… up-regulation of tumor angiogenesis markers PECAM-1/CD31 and VEGFR2, in co-cultures. Finally, we treated GBM tumors using Δ24RGD. Our results showed a significant cell lysis in 3D spheroids. The cell viability was decreased approximately 37%, 54% and 65% with 10, 50 and 100 MOIs, …
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Fabrication and Optimisation of Collagen Scaffolds for Muscle Cell-Supported Angiogenesis
… platelet endothelial cell adhesion molecule-1 (PECAM-1) assembly, which is indicative of the beginnings of vascular network formation, was upregulated. The ratio of HSkMCs to HDMECs was found to be critical for the promotion of stable, interconnected endothelial structures, with additional …
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Development and Optimization of Imaging and Image Quantification Techniques for Tissue-Engineered Blood Vessel Mimics
… BVMs with deployed devices. BBI, H&E, and PECAM-1 staining were all found to be effective assessment methods for silicone BVMs. Overall, the work described in this thesis increased the consistency, standardization, and accuracy of scaffold and BVM assessment in Cal Poly’s Tissue Engineering …
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Characterization of endothelial cells of lymphatic vessels
… Expression of the endothelial markers PECAM/CD31, ICAM-l/CD54, ICAM 2/CDI02 as well as the vascular endothelial growth factor (VEGF) receptor Flk-I, the endothelial cell specific receptors Tie-I, Tie-2, and the lymphatic endothelial specific Flt-4 was identified. When the lesion was …
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Development and Characterization of Tissue Engineered Blood Vessel Mimics Under "Diabetic" Conditions
… platelet endothelial cell adhesion molecule (PECAM), and receptor for advanced glycation end products (RAGE) differs between HUVECs and DHCAECs, as well as between cells cultured in v normal and elevated glucose concentrations. These differences in gene regulation indicate the potential of the …
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Interaktionen von Mikroorganismen und Granulozyten mit Polymer-Oberflächen
… higher expression of integrins (Mac-1) and PECAM-molecules (CD31), accompanied by a degranulation and the induction of an oxidative burst. This can result in a continous cell activation which can lead to a cell exhaustion and eventually to a local immune defect. The shedding of selectine …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… loss by day 10 with a 4-fold reduction in CD31/PECAM+ cells, in comparison to controls of hCB-EPCs in SMC coculture. Changing the coculture media to endothelial growth media (EBM-2 + 2% v/v FBS + EGM-2 supplement containing VEGF, FGF-2, EGF, hydrocortisone, IGF-1, ascorbic acid, and heparin), …
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¿ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM¿
… including the soluble forms of ICAM-1, VCAM-1, PECAM-1 and E-Selectin) in culture supernatants; to assess the in vivo relevance of these markers, they were also measured in the plasma of the same patients; iv) their transcriptomic profile assessed by RNA sequencing to investigate possible …
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Regulatory Mechanisms Underlying the Differentiation of Mesenchymal Stem Cells to Endothelial Cells
… platelet endothelial cell adhesion molecule (PECAM)-1, and vascular endothelial(VE)-cadherin), VEGF R2, Sox18, and enhanced endothelial tube formation. siRNA-mediated-knockdown of Sox18 inhibited EC differentiation whereas Sox18 overexpression induced VEGF R2 expression. Lastly, the inhibitory …
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