Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PEA3"”.
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Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy
… with the poorest overall survival. PEA3 (polyomavirus enhancer activator 3), a member of the Ets family of transcription factors, is overexpressed in triple-negative breast cancer and also correlates with aggressive behavior and poor overall survival. Here, we provide new evidence …
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Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.
… of the protein could not be confirmed as either PEA3 or Ets1, although transactivation data from HepG2 cells suggested PEA3 is important in controlling expression of endogenous PZ.Two further regions, proximal and distal to the PZ transcription start site, were identified by bioinformatic …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… two ETS domain transcription factors, Erm and Pea3, which constitute bona fide integrators of FgfR signaling. By gain- and loss-of-function studies, I demonstrate that transcript levels of erm and pea3 are tightly regulated by Fgf signaling. Detailed analysis of the expression patterns of erm …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… also show that Fgf signaling cascade mediated by Pea3 family of transcription factors are critical for lacrimal gland duct elongation and branching. High-throughput gene expression analysis revealed that Pea3 genes were important for establishing the tissue identity of the lacrimal gland. Loss of …
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Characterization of the Human Cytomegalovirus UL75 Late Gene Promoter
… domain. Mutational analysis demonstrated that a PEA3 element present in this downstream domain is important for promoter activation. In addition, gel shift analysis revealed direct protein binding to the PEA3 element. Deletion and mutational analysis also revealed that multiple sequence elements …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… TIS21 decreases transcription factor (c-Fos, PEA3) of MMPs. We are going to examine the regulatory mechanism of TIS21-mediated MMPs proteoytic activity.
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
… expression of Etv4 and Etv5, which belong to the Pea3 family of transcription factors, vary as a consequence of tumor progression. Etv5 regulates the identity of the cells that give rise to KP tumors, and its expression is lost as tumors evolve. Conversely, Etv4 is not expressed in the adult lung, …