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Showing 1 to 7 of 7 for “"PEA-15"”.
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Die Rolle des Tyrosinkinase-Rezeptors VEGFR-2 im neuronalen Kontext
… PCR identifiziert. Tatsächlich wurde das Protein PEA-15 nicht nur differentiell exprimiert sondern auch als Bestandteil des VEGFR-2-vermittelten Signalwegs identifiziert. Die biologischen Funktionen des Proteins PEA-15 wurden durch VEGF-vermittelte Phosphorylierung reguliert. Die Stimulation durch …
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Role and Regulation of Epha2 In Pancreatic Cancer
… of Ras/MEK/ERK pathway modulators revealed that PEA-15, a protein that sequesters ERK to the cytoplasm, inhibited expression of EphA2. A significant inverse correlation between EphA2 and PEA-15 levels was observed in mouse models of PDAC. In cells where an EGFR inhibitor reduced phospho-Erk, …
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Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2
… known substrates of Omi, the HAX-1 and the ped/pea-15 proteins. HS1-associated protein X-1 (HAX-1) is a mitochondrial protein, degraded by Omi after induction of caspase-dependent apoptosis. Ped/pea-15 is also an anti-apoptotic protein and is cleaved by Omi after induction of caspase-independent …
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Gammabestrahlung führt zur CD95-abhängiger Invasivität in apoptoseresistenten Glioblastomzellen
… diabetes/phosphoprotein enriched in astrocytes-15-kDalton“ (PED/PEA-15) wurde als möglicher Kandidat untersucht. Jedoch konnte nach dem Ausschalten der PED/PEA-15-Expression keine Veränderung in der Inhibierung von GSK3 detektiert werden. Vor diesem Hintergrund sollten die postoperativen …
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Mechanism and Regulation of ERK2 Subcellular Localization
… kinase in the cytoplasm. One of these proteins, PEA-15, prevents ERK2 import in an in vitro system by inhibiting the kinases' ability to interact with nucleoporins. In vivo assays of phosphorylated ERK1/2 show discrete subcellular localization patterns in response to different stimuli that are …
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A STUDY ON THE BIOCHEMICAL AND CELLULAR EFFECTS OF ENVIORMENTAL TOBACCO SMOKE ON ADULT AND DEVELOPING RAT BRAIN BIOCHEMISTRY
… and dephosphorylation of serine116 on PEA-15 indicated greater apoptotic cell death signaling in the brains of ETS exposed animals. β-synuclein was greatly upregulated by ETS, a neuroprotective protein previously reported to exhibit anti-apoptotic and anti-fibrillogenic properties. We …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… PKCα carried pErk1/2 to nuclei after freed from PEA-15pS104 by PKCβ1, and then rapidly degraded by ubiquitination. MAPK docking motif and kinase activity in PKCα were required to carry pErk1/2. Moreover, repetitive application of TPA on mouse skin revealed significant loss of PKCα expression …