Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"PDZ-binding motif"”.
-
A Novel Switch-Like Function of Delta-Catenin In Dendrite Development
… a central Armadillo domain and a C-terminal PDZ-binding motif. This motif associates with PDZ domain-containing proteins, and is crucial for the neuronal functions of delta-catenin. My research has revealed two novel interactions between delta-catenin and the PDZ domain-containing proteins …
-
Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… has been strongly linked to a C-terminal PDZ-binding motif (PBM) that interacts with host post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (ZO-1) (PDZ) domain-containing proteins, facilitating immune dysregulation and …
-
Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ or WWTR1), key players of the Hippo pathway, have been implicated in the liver fibrosis, but the HSC-specific functions of YAP and TAZ are largely unclear. Here we have identified Sirtuin 6 (SIRT6), an NAD+ dependent …
-
Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1
PDZK1 is a four PDZ-domain containing cytoplasmic adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a post-transcriptional, tissue-specific decrease in SR-BI protein level and an increase …
-
Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in bone are controversial, with evidence for each either promoting or inhibiting osteogenesis in vitro. Here, we used in vivo mouse models of combinatorial YAP/TAZ deletion from skeletal lineage cells to investigate their …
-
Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase
… of DGKz activity, but required a function DGKz PDZ-binding motif. In contrast, Rac1 activation required DGKz-derived PA, but not PDZ-interactions, indicating DGKz regulates these Rho GTPases by two distinct regulatory complexes. Interestingly, RhoA bound directly to the DGKz C1A domain, the same …
-
The Tissue Specific Role of Endosome Associated Protein SNX27 in Colonic Inflammation and Tumorigenesis
… the sorting nexin (SNX) family, carries a unique PDZ domain and mediates recycling of endocytosed transmembrane proteins. SNX27 is critical for neurodevelopment and whole body knockout in mice has been found to be embryonically lethal. Although SNX27 is variably expressed in different tissues, its …
-
Taz As A Regulator of Mesenchymal Transformation and Clinical Aggressiveness In Gliomas
… and identified transcriptional co-activator with PDZ-binding motif (TAZ) to be highly associated with the mesenchymal shift. High TAZ expression correlated with worse clinical outcome and higher grade. These data led to the <strong>hypothesis</strong> that TAZ is critical to the mesenchymal …
-
Organization and formation of the apical membrane of epithelial cells
… of domain mutants revealed that the C-terminal PDZ-binding motif of podocalyxin is mainly responsible for its special localization, which it shares with the PDZ protein NHERF-2. Knocking down podocalyxin by RNA interference resulted in retardation of cell growth and epithelial polarization. …
-
Molecular Characterization of the Regulatory Subunits of Voltage -Dependent Calcium Channels From Rat Heart
… gamma1 and shares with it the lack of a PDZ-binding motif that is characteristic of most other gamma subunits. Additionally, the expression of gamma1 mRNA and the long isoform of gamma 6 mRNA is most robust in muscle. These results indicate that gamma 1 and gamma6 may share common …
-
Claudins and tight junction-associated MARVEL proteins at the blood-brain barrier – contribution to paracellular barrier formation
… proteins is found. Despite lack of the typical PDZ binding motif, interaction of Cldn25 with the PDZ1 domain of zonula occludens protein 1 is as pronounced as for classic Cldns. Besides, glycosylation of the extracellular loop of Cldn25 is found to be crucial for the localization at the plasma …
-
Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a range of epithelial-derived cancers, including oral and breast cancers, but their downstream targets and mechanisms of action are …
-
Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
… (YAP)/Transcriptional co-activator with a PDZ-binding motif (TAZ) signaling pathways, hTM cells were seeded on CDMs/XCDMs for 24h. Where applicable, immunocytochemistry, RT-qPCR, Western blotting, enzymatic assays, transmission/scanning electron and atomic force microscopies were performed. …
-
The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… activity, transcriptional coactivator with PDZ-binding motif (TAZ), OC expression and mineral nodule formation. Poncirin prevented adipocyte differentiation via inhibition of lipid droplet accumulation, PPAR-γ, and C/EBP-β expression. Also poncirin prevented osteoclast differentiation via …
-
Role of Phosphorylation In The Regulation of Prmt5
… the C-terminal region of PRMT5 has a recognition motif shared by PDZ domains and 14-3-3 proteins. In order to bind to this motif, 14-3-3 proteins require the C-terminus to be phosphorylated, while PDZ domain recognition is phospho-independent. From these data, a new regulatory mechanism that …
-
Biophysical profiling of YAP/TAZ dependent mechanical responses
Ageing manifests as architectural alterations at the tissue level and a decline in function. Biochemical and mechanical changes in the extracellular matrix (ECM) during ageing result in decreased cellular mechanotransduction. These changes negatively affect intra- and inter-cellular communication, …