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Showing 1 to 20 of 35 for “"PDZ domain"”.

  1. Structural Modes in Proteins: A Case Study in the PDZ Domain

    Poole, Alan Matthew2017

    … architecture in an individual protein (the third PDZ domain from rat PSD95) by measuring physical interactions between all pairs of residues. This global perturbation analysis is performed by making evolutionarily conservative mutations at every position in a protein and observing physical effects …

    utswmed Repository record

  2. Logic and Mechanism of an Evolutionarily Conserved Interaction in PDZ Domain

    Sharma, Rohit2010

    … the physical basis of specificity in the PDZ domain. The co-evolutionary energetic map of the PDZ domain predicts a long range interaction between position 372, a known specificity determinant that directly interacts with ligand, and position 322. Thermodynamic measurements in one PDZ …

    utswmed Repository record

  3. Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins

    Olsen, Courtney, <p><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__orcid.org_0000-2D0003-2D2685-2D0217&d=AwMCAA&c=6vgNTiRn9_pqCD9hKx9JgXN1VapJQ8JVoF8oWH1AgfQ&r=GknWj9_z-7Lf06QrGl-rnjILCN_6eU749v5kKmPni2o&m=M-4it7geQ4Yw40n9p4Gsg0rPRIcOBNZfybcsBSJ72v4&s=vcK31Ot4St4iQ7uGkxEp2P65w-sgO5w82ADz4htasrc&e=" target="_blank">0000-0003-2685-0217</a></p>2019

    … density protein/Discs large-1/Zona occludens-1 (PDZ) domain interactions often regulate the trafficking and signaling potential of other GPCRs, we examined the role of the sst2 PDZ ligand and additional C-terminal residues in controlling its intracellular trafficking, signaling, and regulation. …

    uthsc Repository record

  4. A Global Experimental Analysis of Protein Function: A Case Study in the PDZ Domain

    McLaughlin, Richard Noel, Jr.2011

    … system that measures the cellular function of a PDZ domain in a high-throughput and quantitative manner. We perform a comprehensive single amino acid mutagenesis experiment to show that most positions in the protein are robust to most mutations, and the set of positions that shows sensitivity to …

    utswmed Repository record

  5. Probing peptide binding to the second PDZ domain of hPTP1E using FT-IR and MS

    Papp, Robert2002

    … were evaluated for binding to the second PDZ domain of human protein tyrosine phosphatase 1E using FT-IR and mass spectrometry. This PDZ is known to bind the C-terminal motif X-Ser/Thr-Val. MS demonstrated the formation of a 1:1 complex between PDZ and ENEQVSAV but not with peptides …

    concordia Repository record

  6. Specificity and structural characterization of the PDZ domain from DegS, an extracytoplasmic E. coli protease

    Walsh, Nathan P. (Nathan Peter), 1973-Massachusetts Institute of Technology2002

    … extracytoplasmic-stress response. The C-terminal domain has limited homology to PDZ domains and was thought to be involved in regulation or substrate recognition. A model of this PDZ domain was generated from NMR solution studies and homology modeling. Peptide selection studies identified the …

    mit Repository record

  7. The Structural Properties of Adaptation and Allostery in Proteins: A Case Study in a PDZ Domain

    Raman, Arjun Swaminathan2017

    … path to new specificity in a model protein PSD95pdz3 where one intermediate, a Glycine (G) to Threonine (T) mutation at position 330, removed from the binding site of the protein, maintains native function while simultaneously adapting the protein to an alternate function (termed a 'conditionally …

    utswmed Repository record

  8. Mapping the synapse : synthesis and validation of chemical probes for interrogating PDZ domains

    Iskenderian-Epps, Wendy SMassachusetts Institute of Technology2011

    … in the brain. These complexes consist of many PDZ domain-containing proteins. PDZ domains bind selectively to peptide sequences at the C-termini of partner proteins, and they play an essential role in the regulation of synaptic macromolecular complexes. While many PDZ domain-containing proteins …

    mit Repository record

  9. Protein Mechanics Through X-Ray Crystallography

    White, Kristopher Ian2018

    … of perturbation to a series of members of the PDZ protein family. First, we show that cycles of mutagenesis coupled with X-ray crystallography can reveal an anisotropic, distributed pattern of physical interactions in a PDZ domain, PSD-95 PDZ3. This pattern is functionally important and deeply …

    utswmed Repository record

  10. Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1

    Fenske, Sara AnneMassachusetts Institute of Technology2008

    PDZK1 is a four PDZ-domain containing cytoplasmic adaptor protein that binds the Cterminus of the high-density lipoprotein (HDL) receptor SR-BI. Abolishing PDZK1 expression in PDZK1 knockout (KO) mice leads to a post-transcriptional, tissue-specific decrease in SR-BI protein level and an increase …

    mit Repository record

  11. Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2

    Singh, Supriya

    … to be such a regulator of Omi. It binds to the PDZ domain of Omi via its carboxy-terminus and this interaction significantly increases the proteolytic activity of the enzyme. My project was aimed to investigate the normal function of Omi in cell death and the mechanism of its regulation by …

    ucf

  12. Regulation of the periplasmic stress responses in E. coli and P. aeruginosa

    Cezairliyan, Brent (Brent O.)Massachusetts Institute of Technology2008

    … independent of the autoinhibition of DegS by its PDZ domain. In P. aeruginosa, I have demonstrated that AlgW, the homolog of DegS, cleaves the transmembrane regulator MucA. I have shown similar inhibitory effects of the ortholog of RseB on the ortholog of RseA. Interestingly, the PDZ domain of …

    mit Repository record

  13. Role Of Phosphoglucan Phosphatases In Regulating Starch Degradation In Plants

    Silver, DylanGraduate Studies2013

    … contain phosphatase and carbohydrate-binding domains, but LSF1 also possesses a protein-protein interaction PDZ domain. I show that LSF1 is chloroplastic and necessary for proper starch breakdown, as lsf1 mutants accumulate starch at the end of night. LSF1 lacks phosphatase activity and …

    calgary Repository record

  14. Isothermal Titration Calorimetry Studies Of Protein-Mediated Interactions And Preliminary Structural Studies Of Tandem Pdz1-2 Domain Of Psd-95 Protein

    Jankovic, Ana2010

    … such interactions for two proteins, the PDZ domain and frataxin, involving peptide and metal binding ligands, respectively. The three component projects of this work comprised (1) thermodynamic analysis of PDZ domain binding using calorimetry; (2) X-ray crystallographic structural studies …

    wayne-thes Repository record

  15. A Novel Switch-Like Function of Delta-Catenin In Dendrite Development

    Baumert, Ryan, <p>0000-0003-0487-4912</p>2020

    … delta-catenin possesses a central Armadillo domain and a C-terminal PDZ-binding motif. This motif associates with PDZ domain-containing proteins, and is crucial for the neuronal functions of delta-catenin. My research has revealed two novel interactions between delta-catenin and the PDZ …

    uthsc Repository record

  16. From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster

    Mulinari, ShaiDepartment of Experimental Medical Science, Lund Univeristy2008

    … RhoGEFs, LARG (Leukemia-associated RhoGEF), PDZ-RhoGEF and p115 RhoGEFs. In addition to a catalytic module, DRhoGEF2 encompasses an N-terminal PSD-95/Dlg/ZO-1 (PDZ) domain, a Regulator of G-protein Signaling (RGS) domain and a cysteine-rich diacylglycerol (DAG)-binding domain in the central …

    lund Repository record

  17. Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics

    Bennett, E2008

    … is already a broadly studied area, whereas the PDZ domaininteractions is a relatively recent area of study. The literature in these areas is reviewed.This research project designed and synthesised novel molecules which were capable ofmodulating the dynamics of the tubulin dimers or the …

    salford Repository record

  18. Mechanisms of Eph/ephrin mediated cell-cell communication

    Zimmer, ManuelLudwig-Maximilians-Universität

    … tyrosine phosphorylation of the cytoplasmic domain, initiating docking sites for downstream signaling adaptors. Moreover, ephrinB ligands can signal by interactions with various PDZ-domain containing proteins. Using a broad range of in vitro assays the presented work demonstrates that upon …

    lmu-germany Repository record

  19. Structural characterization of the type II secretion system of Aeromonas hydrophila

    Flath, BenjaminUniversity of Saskatchewan2013

    … Aeromonas hydrophila codes for a 31 kDa, three domain, bitopic inner membrane protein. The components of the ExeC protein include an amino-terminal cytoplasmic domain, a trans-membrane helix and two periplasmic domains. The two periplasmic domains are involved in recognition and selection of …

    sask Repository record

  20. Role of the LPA2 Receptor in Protecting Against Apoptosis

    E, Shuyu2016

    … enable it to form macromolecular complexes with PDZ and LIM domain proteins, which link it to G protein-independent signaling networks. Using deletion and site-specific mutagenesis, we mapped out C311xxC314 motif of LPA<sub>2</sub>-CT that is required for interaction with LIM domain proteins …

    tenn-hsc Repository record

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