Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PDX model"”.
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First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates
… of tracer concentration in indicator-dilution modeling. This discounts additional information that may be available from the first-order speckle statistics in a CEUS image. Heterogeneous vascular networks, typical of tumor-induced angiogenesis, lead to heterogeneous contrast enhancement of the …
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Multiplexed angiogenic biomarker quantification on single cells
… for the development of an accurate angiogenesis model. To gain insights on the involvement of these angiogenic receptors in angiogenesis, I develop a method to quantify receptor concentrations as well as the cell-by-cell heterogeneity. I establish protocols to measure cell membrane VEGFR, NRP1, …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… and inhibits primary tumor growth in the TNBC PDX model, in the presence of macrophages and NK cells.</p>
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Studying the Clonal Origins of Drug Resistance in Human Breast Cancers
… repopulation dynamics, drug induced chromatin remodelling or differential transcription factor binding, that can be transient or permanent in nature. This thesis will outline experiments using high complexity molecular barcodes to trace the fate of individual cellular clones in the development of …
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Quantitative analysis of signaling networks in proneural glioblastoma
… progression in a genetically engineered murine model of proneural GBM, we quantified signaling networks using mass spectrometry. We identified oncogenic signaling associated with the GBM model, such as increased phosphorylation of ERK1/2, P13K, and PDGFRA, relative to murine brain. …
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Cd47+ Exosomes Facilitate Effective Targeting of Oncogenic Kras In Pancreatic Cancer
… orthotopic human pancreatic cancer models, genetically engineered mouse models (GEMMs), as well as in a patient derived xenograft (PDX) model of pancreatic cancer, and significantly increased their overall survival. In addition we demonstrate that the enhanced efficacy iExosomes is …
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Computational Approaches to Understand Chemoresistance & Tumor Evolution Using Longitudinal Clinical Data and Lineage Tracing
… and CDKN2A deletions. A machine-learning model integrating immune, transcriptomic and genomic features accurately predict pCR, with validation in a blinded cohort.</p> <p>By tracking these tumors pre and post-chemotherapy (N=131), using RNASeq and whole-exome sequencing, we interrogated …
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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
… 4) dasatinib at the dosages used in pre-clinical models can reach desired drug exposure and effect in patients predicted by pharmacokinetic & pharmacodynamic (PK & PD) modeling; and 5) an LCK degradation approach can achieve better therapeutic efficacy than dasatinib in T-ALL. …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… in pancreatic patient-derived xenograft (PDX) tumors; and 2. The use of shRNA technology on pancreatic PDX tumors can elucidate synthetic lethal partners to overcome therapeutic resistance to PARP inhibition. To test this hypothesis, I set out to first further characterize the hereditary …
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Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… of reducing cell viability in all 4 cell line models treated. Notably this reduction did not correlate with DR5 surface expression but was consistent with observations in the literature. The reduction of viability was promising and the addition camptothecin improved this potency. The combined …
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CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… withdrawal. However, a lack of robust in vivo models of clinical chemoresistance in human AML hinders our understanding of these mechanisms. To address this, I aimed to generate in vivo models of truly chemoresistant AML to investigate non-genetic mechanisms of chemotherapy resistance. I …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… cancer brain metastasis in multiple preclinical models, including two syngeneic immunocompetent models and a CCR2-deficient model, although the CCR2 antagonist PF-04136309 significantly blocks monocyte trafficking in blood and CCR2<sup>+</sup> myeloid cell infiltration into the brain TME. Our …