Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 125 for “"PDT"”.
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Synthesis and Photophysics of Varied Substituted DPNDs for Potential PDT Applications
Understanding how molecular architecture and solvent polarity govern excited-state dynamics is fundamental to developing functional chromophores for photo-energy conversion and manipulation for opto-electronic applications. Here, the photophysical properties of three dipyrrolonaphthyridinedione …
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
Photodynamic Therapy (PDT) holds great promise for the treatment of head and neck (H&N) carcinomas where repeated loco-regional therapy often becomes necessary due to the highly aggressive and recurrent nature of the cancers. Conventional surgery, chemotherapy and radiotherapy approaches cause …
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The synthesis of aza-dipyrromethenes as potential pdt agents and measurement of singlet oxygen generation.
Photodynamic therapy is a relatively new treatment for various cancers and other diseases using a photosensistiser that produces cytotoxic singlet oxygen (1O2) after light irradiation. Current approved photosensitisers have limitations, such as a low extinction coefficient in the desired …
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Polyazine-Bridged Ru(II),Pt(II) Trimetallic and Tetrametallic Supramolecular Complexes Exhibiting Unusual Excited State Dynamics Important in Catalysis and PDT Drug Development
The goal of this research was to develop structurally diverse polyazine-bridged Ru(II),Pt(II) trimetallic and tetrametallic supramolecular complexes and study the impact of component variation on the redox, spectroscopic, and excited state properties that influence photoinduced charged separation …
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Investigation on the Molecular Mechanism of Photorejuvenation in Photodynamic Therapy
… of long-term UV exposure. Photodynamic therapy (PDT) is a therapeutic modality for cutaneous malignant and premalignant condition. Recently, several clinical studies reported that the PDT has photorejuvenation effects on the aged skin. In the previous report, which is examined direct effect of …
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Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy
… over years that the photodynamic therapy (PDT) has effects on the rejuvenation of photoaged skin. However, there have been no studies on the intracellular mechanism of photorejuvenation following PDT. The purpose of this study was to investigate the effects of PDT on the signal transduction …
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Parental Differential Treatment for Adult Children: Interactions, Implications and Interventions
Parental Differential Treatment (PDT) is the conscious or unconscious action of providing one sibling more favorable treatment over another. PDT has consequences for children‟s lives. Several consequences have been identified for children who experience PDT; however there is a dearth of literature …
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Histological Changes in Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in a Photoaged Mouse Model
… material in the dermis. Photodynamic therapy (PDT) is a noninvasive technique used in the treatment of various skin disorders, and recently it has been shown to be effective for photoaged skins. However, the histological studies of PDT in animal model have rarely been reported. Objectives: I …
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First Trimester Screening and Its Impact On Uptake of Diagnostic Testing
… accuracy of prenatal diagnostic testing (PDT). Since FTS has been available, a decrease in the number of women who pursue PDT has been observed. This study sought to determine if there has been a significant change in the amount of PDT performed in our clinics, if the type of FTS result …
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Avaliação do uso de nano carreadores de ramnolipídeos associados ao fotossensibilizador azul de Taylor na terapia fotodinâmica antimicrobiana contra Staphylococcus aureus: estudo in vitro
… such as Antimicrobial Photodynamic Therapy (PDT). With the advancement of science, nanotechnology techniques are increasingly present, promoting the enhancement of existing techniques. This study evaluated, in vitro, the efficacy of PDT coupled with carrier nanotechnology against …
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Photodynamic Therapy As An Effective Therapeutic Approach In Mame Models Of Triple Negative And Inflammatory Breast Cancers
<p>Introduction: Photodynamic therapy (PDT) is a minimally invasive, FDA approved therapy for</p> <p>treatment of several indications including endobronchial and esophageal cancers that are</p> <p>accessible to light. Triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC)</p> …
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Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in the Patients with Actinic Keratosis: A Histological Analysis
… material in the dermis. Photodynamic therapy (PDT) is one of many treatment options available for photoaging; it has been shown to be effective, whereas the data on most other studies is based on clinical observation. Objectives: I investigated whether 5-aminolevulinic acid (ALA)-PDT induced …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
… Africa is increasing. Photodynamic therapy (PDT) has been shown to be an effective treatment modality, through topical administration, for treatment of non-melanoma skin cancers. Our group investigates hypericin-induced PDT (HYP-PDT) for the treatment of both non-melanoma and melanoma skin …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
… as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper tumor imaging and avoids …
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Modeling The Active Site Of [NiFe]-Hydrogenase
… thiolates. Previous work has shown that Ni(dppe)(pdt) reacts with Fe2(CO)9 in dichloromethane to form (CO3)Fe(pdt)Ni(dppe). The Fe(I)Ni(I) complex, (CO)3Fe(pdt)Ni(dppe), was readily protonated with HBF4 to give the corresponding bridging hydride. This complex served as the first example of a …
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Synthesis of Phenothiazinium Derivatives
<p>Photodynamic Therapy (PDT) of cancer involves radiating photosensitizing drugs with light in tumors, which results in generating active singlet oxygen that kills cancer cells. Photosensitizers currently used in PDT are of low quantum yield and require high energy radiation, normally laser. …
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Incorporation of cyanide ligands into models of [FeFe]- and [NiFe]-hydrogenase
… triarylboranes to the [FeFe]-H2ase models [Fe2(pdt)(CO)4(CN)2]2‒ and [Fe2(adt)(CO)4(CN)2]2‒. Treatment of two equivalents of borane to [Fe2(pdt)(CO)4(CN)2]2‒ formed the 2:1 adduct [Fe2(pdt)(CO)4(CNBR3)2]2‒. Attempts to model the inequivalent hydrogen bonding environment of [FeFe]-H2ase with BPh3 …
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Photodynamic therapy against multidrug-resistant oral strains of Candida spp
… Within this framework, photodynamic therapy (PDT) may be a viable option for treating yeast infections. In this context, the purpose of this work is to evaluate and compare, through a clinical-laboratory multidisciplinary approach, commercially available protocols and new procedures based on …
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EXPLORING HETEROSTRUCTURED UPCONVERSION NANOPARTICLES: FROM RATIONAL PARTICLE ENGINEERING TO BIOMEDICAL APPLICATIONS
… nanoparticle (UCNP)-based photodynamic therapy (PDT) with unique anti-stokes luminescence features are of great interest. UCNP-based PDT affords greater tissue penetration depths than that of visible lights and serves as suitable nanoplatforms carrying photosensitizers as well. However, …
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Effects of combination therapies on age-related macular degeneration
… factor (VEGF) drugs, photodynamic therapy (PDT) and steroids. All three require invasive eye procedures that carry their own risks. The possibility of more effective treatments by combining these therapies is being tested through clinical trials. Studies of combined PDT and anti-VEGF, …
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