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Showing 1 to 20 of 20 for “"PDLLA"”.
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Vergleichende Untersuchungen der Hämokompatibilität unterschiedlicher Polymere (Polypropylen, Cuprophan, PDLLA, PDLLA/HEMA) im Hinblick auf Thrombozytenadhäsion und -aktivierung
… (polypropylene, cuprophane (non-resorbable) and PDLLA, PDLLA/HEMA (resorbable)) are compared with regard to their haemocopatibility and suitability as an intravascular implant. The biomaterials are first incubated with isolated, discoid and non-activated platelets, drawn from fresh human blood. …
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Amphiphilic Poly(2-isopropyl-2-oxazoline)-block-poly(lactide) Nanoparticles as Drug Delivery Vehicles
… (PiPOx-b-PDLLA and PiPOx-b-PLLA) nanoparticles was obtained via Fluorescence Spectroscopy. Additionally, loading and release studies were carried out with hydrophobic curcumin molecules to outline the potential of the amphiphilic block copolymers in drug …
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Synthesis and Characterization of Functional Biodegradable Polyesters
… preparation of star-shaped, poly(D,L-lactide)s (PDLLA)s of controlled molar mass, narrow molar mass distributions, and well-defined chain end functionality. Various modifications of star-shaped PDLLA resulted in macromolecules with tailored functionalities for biomedical applications. Star-shaped …
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Mechanical and biological augmentation of allograft and synthetic graft in impaction bone grafting
… a synthetic graft, Poly (DL-lactic acid),<br/>(PDLLA) as a tissue engineering scaffold and a graft extender in IBG.<br/><br/>• To investigate methods to improve graft compaction and reduce fracture risk<br/>in IBG.<br/><br/>Methods:<br/><br/>Part I: The biocompatibility and mechanical properties …
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Entwicklung einer biodegradierbaren Harnleiterschiene : In-vitro-Analytik von Poly(D,L-Lactid) als Homo- und Copolymer, Formgebungs-Technologie, Oberflächenmodifizierung und tierexperimentelle Untersuchung im Schaf-Modell
… homo- and copolymers poly(D,L-lactide) (PDLLA), poly(D,L-lactide-co-trimethylene-carbonate) (PDLLA-co-TMC), poly(D,L-lactide-co-glycolide) (PDLLA-co-Gly) as derivatives of lactic acid or glycolic acid and surface modifications with hydroxyethylenemethacrylate (HEMA) and …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… poly(ethylene oxide-b-D,L-lactide), (PEO-b-PDLLA), block copolymers with controlled molecular weights and good functionality on the poly(ethylene oxide) end for the design of potential core-shell delivery vehicles for HIV drugs. PEO-b-PDLLA block copolymer was used as a polymeric nanocarrier …
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Induktion und Prophylaxe Implantat assoziierter Knocheninfektionen am Modell eines antiinfektiv beschichteten Marknagels
… gentamicin-loaded poly-(D,L-lactide) (PDLLA) coating of orthopedic devices. In vitro, elution kinetics of gentamicin and furthermore, biocompatibility and effectiveness in preventing implant-related osteomyelitis should be studied in vivo. Coating of commercial steel implants was …
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Coaxial double-walled microspheres for drug and gene delivery applications
… core surrounded by a poly(D,L-lactic acid) (PDLLA) or poly(L-lactic acid) (PLLA) shell layer. The first study involves bridging the experimental work on the fabrication of double-walled microspheres from CEHDA and the simulation work on the generation of compound droplets from the same …
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Freisetzungsverhalten von unterschiedlich hydrophil/hydrophoben Modellsubstanzen aus Poly-(D,L-lactid)- und Poly-(D,L-lactid)-co-PEO-co-poly-(D,L-lactid)-Mikrosphären und pharmazeutische Anwendungen
… and drugs from degradable poly-(D,L-lactide) (PDLLA) and poly-(D,L-lactide)-co-PEO-co-poly-(D,L-lactide) (ABA) microspheres as well as poly-(D,L-lactide-co-TMC)(90:10) nanospheres in PBS-buffer are characterised. To investigate the release behaviour, three different hydrophilic/hydrophobic …
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Bioresorbable Electrospun Tissue Scaffolds of Poly(ethylene glycol-b-lactide) Copolymers for Bone Tissue Engineering
… To accomplish this, PEG-PLLA and PEG-PDLLA diblock copolymers were synthesized with target molecular weights of 42,000 g/mol (PEG:2000, PLLA or PDLLA:40,000). Next, these two polymers and commercially available PLLA and PDLLA were electrospun to form scaffolds with fibers of diameters …
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Langzeituntersuchung zur In-Stent-Restenose eines neuen biodegradierbaren, wirkstoffbeladenen, intravaskulären Polylaktidstents nach Implantation in porcine Koronararterien
… of a bioresorbable poly(D,L)-lactic acid (PDLLA). A modified balloon catheter for stent deployment was developed according to the mechanical stent properties. Twelve paclitaxel-loaded (170 microg) polylactide stents, 12 unloaded polylactide stents, and 12 316L bare metal stents were …
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Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
… poly (L-lactide) (PLLA) or poly (D, L-lactide) (PDLLA) incorporation on crystallinity of pentablock copolymers and in vitro release profile of triamcinolone acetonide (selected as model drug) from nanoparticles was also evaluated. Pentablock polymer with proper ratio PDLLA/PCL was amorphous in …
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Novel strategies for the inhibition of biofilm formation on polymer surfaces
… of the commercially available poly(D,L lactide) (PDLLA) (Resomer® 208), a polymer with long history in biomedical applications. Subsequently the release behavior of the halogenated furanone-loaded PDLLA films was investigated in an in vitro experiment. The RIP peptide (YSPWTNF) was used as an …
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Influence of Electrostatic and Intermolecular Interactions on the Solution Behavior and Electrospinning of Functional Nanofibers
… electrospinning. Star-shaped poly(D,L-lactide)s (PDLLAs) were end-functionalized with adenine (A) or thymine (T) units. The complementary hydrogen bonding between the adenine and thymine lead to thermoresponsive rheological behavior for mixtures of PDLLA-A and PDLLA-T. The mixtures could be …
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The Design of Biodegradable Polyester Nanocarriers for Image-guided Therapeutic Delivery
… oxide)-b-poly(D,L-lactic acid) (PEO-b-PDLLA) based nanoparticles were produced to range from 100-200 nm in size. They were fluorescently labeled with a hydrophobic dye 6-13 bis(triisopropylsilylethynyl) pentacene (TIPS pentacene) at an optimal loading of 0.5 wt% with respect to the …
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Biokompatibilität resorbierbarer Polymere in der Mund-, Kiefer- und Gesichtschirurgie : eine evidenzbasierte Analyse
… sind die Ergebnisse mit dem Copolymer (PDLLA) und den Poly-meren Caprolacton und Tyrosin. Vor der Einführung in die Klinik, bedarf es rando-misierter kontrollierter Humanstudien, die das Degradationsverhalten über einen aus-reichend langen Beobachtungszeitraum untersuchen.
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Modulation of cell morphology and function using synthetic biodegradable polymers
… block copolymer of PEG and poly(DL-lactic acid) (PDLLA). We demonstrated that engineering of surface chemistry and microstructure of substrates could induce proper cell shape and function.
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Development and characterization of biodegradable microspheres containing selected antimycobacterials.
… moderate (11 kD, R202H) MW poly(D, L-lactide) (PDLLA); materials which demonstrated excellent sprayability and dramatically modulated the release of drug when combined compared to their use alone. Drug release showed a remarkable dependence on blend, dramatic acceleration being observed between …
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3D scaffolds for tissue engineering produced by microfabrication technology
… poly(D, L lactic acid) - tricalcium phosphate (PDLLA-TCP 90:10) scaffolds. Furthermore, once the cells had reached the confluent stage, osteogenic media was used during cell culture to induce matrix formation. The newly formed matrix could provide a physical support forming an osteoblast sheet …
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Studien zur kontrollierten Freisetzung biologisch aktiver Substanzen aus resorbierbaren Nano- und Mikrosphären
The aim of the thesis was the preparation and characterization of resorbable drug delivery systems on the basis of nano- and microspheres, used as sustained release systems and for drug targeting. Using acetylic acid, the peptide hormone insulin and the serin protease thrombin studies were carried …