Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"PDK4"”.
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Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
… inflammation. Pyruvate Dehydrogenase Kinase 4 (PDK4) is upregulated in the skeletal muscles of many cancer cachexia models and has been shown to drive muscle wasting in some conditions. We show that despite being upregulated in an orthotopic mouse model of PDAC cachexia, whole-body deletion of …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
<p>Pyruvate dehydrogenase kinase 4 (PDK4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). The PDC catalyzes the conversion of pyruvate to acetyl-CoA and it is an important control point in glucose and pyruvate metabolism. Previous …
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The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
… production. To assess the importance of PDK2 and PDK4 in regulation of the PDC to maintain glucose homeostasis, PDK2 knockout (KO), PDK4 KO, and PDK2/PDK4 double knockout (DKO) mice were generated. PDK2 deficiency caused higher PDC activity and lower blood glucose levels in the fed state while …
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Differential gene expression and molecular mechanisms associated with development of pale, soft and exudative (PSE) turkey meat
… Pyruvate dehydrogenase kinase isozyme 4 (PDK4), which regulates glucose oxidation, showed substantial decreased expression with both microarray (FC = -25.9) and RNA-Seq (FC = -14.1); thus, this gene was chosen as a candidate gene for further evaluation. The protein abundance of PDK4 was …
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Adaptations of skeletal muscle pyruvate dehydrogenase kinase in response to food-restriction in mitochondrial subpopulations
… by intrinsic PDH kinases (predominantly PDK2 and PDK4 isoforms), but the understanding of the PDK isoform distribution and adaptation to nutritional stresses has been restricted to mixed mitochondrial populations, and not delineated between subsarcolemmal (SS) and intermyofibrillar (IMF) …
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The Role of Metabolic Inflexibility in Heart Failure
… HF. Since pyruvate dehydrogenase (PDH) kinase 4 (PDK4) is the predominant PDK found in the heart and PDK4 expression in the heart increases with high circulating fat levels, I employed a genetic approach to modulate its expression in cardiomyocytes specifically. This animal model allows us to …
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Modulation of exercise-induced gene expression in human skeletal muscle by exercise intensity, training status and short-term endurance training
… induced an increase in PGC-1α. FOXO1A, and PDK4 mRNA abundance in both untrained and trained muscle. This may form part of a transcriptional response that contributes to exercise-induced alterations in skeletal muscle metabolism such as glucose sparing and increased fat oxidation during …
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Pyruvate dehydrogenase activity in response to skeletal muscle contraction at two stimulation frequencies in pyruvate dehydrogenase kinase 2 knockout mice
… while total PDK actitvity was -4 fold lower. PDK4 protein was not different, however PDKI partially compensated for the lack of PDK2 and was -56% higher than WT. PDKI is a very potent inhibitor of the PDH complex due to its phosphorylation site specificity and allosteric regulation. These …
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Hepatic gene networks due to the trans-10, cis-12-conjugated linoleic acid supplementation in growing male mice
… oxidation (Acox1), glyceroneogenesis (Pck1 and Pdk4). The results suggest that the increased liver weight in response to trans-10, cis-12-CLA may be due to increased fatty acid uptake, stimulated TG synthesis, enhanced formation of lipid droplets as well as insufficiently induced VLDL …
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The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency
… of substrate utilisation including FOXO1A and PDK4. This may form part of a transcriptional response to exercise that promotes fat oxidation and glucose sparing in the recovery from exercise. These results suggest that an acute bout of exercise induces a transient response in intracellular …
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Desnutrição proteica perinatal induz mudanças na expressão de genes metabólicos de ratos : potencial efeito da atividade física materna
… no tecido adiposo uma menor expressão na PDK4, CT e CPT1b aos 30 dias de filhotes desnutridos, mas que se normalizaram aos 90 dias. No fígado, alguns resultados foram similares, mas também foi observado maior expressão gênica de CT e FAS aos 30 dias nos filhotes desnutridos. A revisão …
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Interactive Effects of Macronutrients on Obesity and Metabolic Syndrome Development
… protein also induced pyruvate dehydrogenase 4 (PDK4) in skeletal muscle, suggesting decreased glucose oxidation but not glycolysis. Low protein increased plasma adiponectin (P<0.05), suggesting an enhanced role of adipose in energy metabolism. Increased protein efficiency by fructose may be …
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Molecular Mechanisms Governing the Pharmacology of LDT409 for the Treatment of Metabolic Disease
… of fasting-associated target genes (e.g., Fgf21, Pdk4), suggesting that LDT409 may mimic fasting to ameliorate fatty liver disease (Chapter 3). Lastly, we explored whether LDT409 induced a “fasting phenotype” to prolong the catabolic state and found that LDT409 yielded a similar response to …
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Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… related to energy utilization such as Glut4 and Pdk4. Thus we hypothesized that Scriptaid might regulate Sost and Glut4 expression in osteocytes. To investigate the effect of Scriptaid on osteocytes, we treated a mouse osteocytic cell line, Ocy454-12H, with Scriptaid. Unexpectedly, Scriptaid …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… to LWS. Greater pyruvate dehydrogenase kinase 4 (PDK4) and forkhead box O1 (FoxO1) mRNA were found in skeletal muscle and white adipose tissue of 56-day-old HWS than LWS. Expression of peroxisome proliferator-activated receptor γ (PPARγ) in all adipose tissue depots was greater (P < 0.05) in LWS …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
… was required for the induction of PGC1α, PPARα, PDK4 and UCP1 by β3-AR activation in BAT of mice. Similarly, lipolysis was required for the maximal induction of oxidative genes in cultured brown adipocytes (BAs), while increasing endogenous FAs elevated their expression. Pharmacological …
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Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
… of several metabolic genes such as: Ogt, Oga, Pdk4, Glut4, Ptpn1, Igf2, H19, and FoxO1. Furthermore, with the exception of Glut4, methylation patterns in fathers were preserved within male offspring. These novel findings suggest that offspring have a phenotype that is epigenetically programmed …
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The Effects of Macronutrient and Energy Availability on Metabolic Responses to Exercise: Implications for Training Adaptation
… (P=0.41). HFAT induced greater increases in PDK4 (P=0.003), CD36 (P=0.05) and CPT1 (P=0.03) mRNA in the recovery period from afternoon exercise compared with HCHO. p70S6K activity was higher (P=0.08) at 3-h post-afternoon exercise in HCHO versus HFAT (72.7 ± 51.9 vs 44.7 ± 27 fmol.min-1 …
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
… in mitochondrial fatty acid j3-oxidation (PDK4, UCP3, mCPTl and MCD), transcription of glucose transporters (GLUTI and GLUT4) was not significantly altered. Contrary to our expectations, ACCa. and ACCj3 were similarly regulated in both ventricles, indicating that the expression of these …
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Exercise-induced cell signalling responses of human skeletal responses of human skeletal muscle: the effects of reduced carbohydrate availability
… Before and 3 h post-exercise, mRNA content of PDK4, Tfam, COXIVand PGC-1a were greater in LOW compared with HIGH (P < 0.05) whereas CPT1 showed trend towards significance (P = 0.09). However, only PGC-1a expression was increased by exercise (P < 0.05) where 3-fold increases occurred independent …
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